General Information of Drug Metabolite (DM) (ID: DM002768)
DM Name
9-Aminocamptothecin metabolite M2
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 1A1 (CYP1A1) DME0006 Unclear - Unclear NSC-603071 [1]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear NSC-603071 [1]
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
Cytochrome P450 1A1 (CYP1A1) DME0006 Unclear - Unclear NSC-603071 [1]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear NSC-603071 [1]
Full List of Drug(s) That Produce This DM By Metabolism
NSC-603071 DR1862 Phase 2 Ovarian cancer
References
1 Cytochrome P450 3A-mediated metabolism of the topoisomerase I inhibitor 9-aminocamptothecin: impact on cancer therapy. Int J Oncol. 2014 Aug;45(2):877-86.

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