Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME0006)
DME Name	Cytochrome P450 1A1 (CYP1A1), Homo sapiens
Synonyms	Cytochrome P450 family 1 subfamily A member 1; Hydroperoxy icosatetraenoate dehydratase; Cytochrome P450-C; Cytochrome P450-P1; Cytochrome P450 form 6; CYP1A1; CYPIA1
Gene Name	CYP1A1
UniProt ID	CP1A1_HUMAN
Gene ID	1543
EC Number	EC: 1.14.14.1 (Click to Show/Hide the Complete EC Tree) Oxidoreductase Oxygen paired donor oxidoreductase Flavin/flavoprotein donor oxidoreductase EC: 1.14.14.1
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome (loading-time for this interactome depdends on the speed of web connection)
Interactions between Microbiome and DME (MICBIO) Jump to Detailed Interactome Data
Interactions between Xenobiotics and DME (XEOTIC) Jump to Detailed Interactome Data
Interactions between Host Protein and DME (HOSPPI) Jump to Detailed Interactome Data

Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence	MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
Structure	4I8V ; 6DWM ; 6DWN
Pathway	Chemical carcinogenesis (hsa05204 )
	Metabolic pathways (hsa01100 )
	Metabolism of xenobiotics by cytochrome P450 (hsa00980 )
	Ovarian steroidogenesis (hsa04913 )
	Retinol metabolism (hsa00830 )
	Steroid hormone biosynthesis (hsa00140 )
	Tryptophan metabolism (hsa00380 )
Function	This enzyme is involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. It catalyzes the hydroxylation of carbon-hydrogen bonds and exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16- alpha positions. It also displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation and Catalyzes the epoxidation of double bonds of certain PUFA.

Full List of Drug(s) Metabolized by This DME
Drugs Approved by FDA			Click to Show/Hide the Full List of Drugs: 65 Drugs
Thalidomide	Drug Info	Approved	Breast cancer	ICD11: 2C60	[1], [2]
Tamoxifen citrate	Drug Info	Approved	Breast cancer	ICD11: 2C60	[3]
Erlotinib hydrochloride	Drug Info	Approved	Lung cancer	ICD11: 2C25	[4]
Estradiol acetate	Drug Info	Approved	Acquired prion disease	ICD11: 8E01	[5]
Estradiol cypionate	Drug Info	Approved	Acquired prion disease	ICD11: 8E01	[6]
Estrone	Drug Info	Approved	Menopausal disorder	ICD11: GA30	[7]
Nicotine	Drug Info	Approved	Nicotine dependence	ICD11: 6C4A	[8]
Capmatinib	Drug Info	Approved	Lung cancer	ICD11: 2C25	[9]
Dronabinol	Drug Info	Approved	Anorexia nervosa	ICD11: 6B80	[10]
Ozanimod	Drug Info	Approved	Multiple sclerosis	ICD11: 8A40	[11]
Diclofenac sodium	Drug Info	Approved	Osteoarthritis	ICD11: FA00	[12]
Prazosin	Drug Info	Approved	Prostatic hyperplasia	ICD11: GA90	[13]
Progesterone	Drug Info	Approved	Premature labour	ICD11: JB00	[14]
Imatinib mesylate	Drug Info	Approved	Chronic myelogenous leukaemia	ICD11: 2A20	[1], [15], [16]
Cannabidiol	Drug Info	Approved	Lennox-Gastaut syndrome	ICD11: 8A62	[17]
Capsaicin	Drug Info	Approved	Herpes zoster	ICD11: 1E91	[18]
Ethinyl estradiol	Drug Info	Approved	Menopausal disorder	ICD11: GA30	[19]
Sunitinib malate	Drug Info	Approved	Renal cell carcinoma	ICD11: 2C90	[20]
Tretinoin	Drug Info	Approved	Acne vulgaris	ICD11: ED80	[21]
Daunorubicin	Drug Info	Approved	Acute myeloid leukaemia	ICD11: 2A60	[22]
Febuxostat	Drug Info	Approved	Hyperuricaemia	ICD11: 5C55	[23]
Copanlisib	Drug Info	Approved	Follicular lymphoma	ICD11: 2A80	[24]
Alitretinoin	Drug Info	Approved	Kaposi sarcoma	ICD11: 2B57	[25]
Carvedilol	Drug Info	Approved	Congestive heart failure	ICD11: BD10	[26]
Flutamide	Drug Info	Approved	Prostate cancer	ICD11: 2C82	[27]
Haloperidol decanoate	Drug Info	Approved	Agitation/aggression	ICD11: 6D86	[28]
Nevirapine	Drug Info	Approved	Human immunodeficiency virus infection	ICD11: 1C60	[29]
Tivozanib	Drug Info	Approved	Renal cell carcinoma	ICD11: 2C90	[30]
Toremifene citrate	Drug Info	Approved	Breast cancer	ICD11: 2C60	[31]
Umeclidinium bromide	Drug Info	Approved	Chronic obstructive pulmonary disease	ICD11: CA22	[32]
Fluvastatin sodium	Drug Info	Approved	Hypertriglyceridaemia	ICD11: 5C80	[33]
Lesinurad	Drug Info	Approved	Uncontrolled gout	ICD11: FA25	[34]
Mercaptopurine	Drug Info	Approved	Acute lymphoblastic leukemia	ICD11: 2B33	[35]
Riluzole	Drug Info	Approved	Amyotrophic lateral sclerosis	ICD11: 8B60	[36]
Amiodarone hydrochloride	Drug Info	Approved	Ventricular tachyarrhythmia	ICD11: BC71	[37]
Clonidine	Drug Info	Approved	Essential hypertension	ICD11: BA00	[38]
Loxapine succinate	Drug Info	Approved	Schizophrenia	ICD11: 6A20	[39]
Ponatinib hydrochloride	Drug Info	Approved	Acute lymphoblastic leukemia	ICD11: 2B33	[40]
Solifenacin succinate	Drug Info	Approved	Overactive bladder	ICD11: GC50	[41]
Tasimelteon	Drug Info	Approved	Insomnia	ICD11: 7A00	[42]
Theophylline	Drug Info	Approved	Chronic obstructive pulmonary disease	ICD11: CA22	[43]
Triclosan	Drug Info	Approved	Malaria	ICD11: 1F40-1F45	[44]
Acetaminophen	Drug Info	Approved	Anaesthesia	ICD11: 8E22	[45]
Lenvatinib	Drug Info	Approved	Thyroid cancer	ICD11: 2D10	[46]
Procarbazine	Drug Info	Approved	Anaplastic large cell lymphoma	ICD11: 2A90	[47]
Riociguat	Drug Info	Approved	Pulmonary hypertension	ICD11: BB01	[48]
Troglitazone	Drug Info	Approved	Diabetes mellitus	ICD11: 5A10	[49]
Azilsartan	Drug Info	Approved	Hypertension	ICD11: BA00-BA04	[50], [51]
Clofibrate	Drug Info	Approved	Hypertriglyceridaemia	ICD11: 5C80	[52]
Granisetron hydrochloride	Drug Info	Approved	Functional nausea/vomiting	ICD11: DD90	[53]
Oxaliplatin	Drug Info	Approved	Colorectal cancer	ICD11: 2B91	[54]
Pentamidine isethionate	Drug Info	Approved	Pneumocystis pneumonia	ICD11: CA40	[55]
Sulindac	Drug Info	Approved	Rheumatoid arthritis	ICD11: FA20	[56]
Chloroquine	Drug Info	Approved	Malaria	ICD11: 1F40	[57]
Dacarbazine	Drug Info	Approved	Melanoma	ICD11: 2C30	[58]
Erythromycin stearate	Drug Info	Approved	Acute upper respiratory infection	ICD11: CA07	[59]
Meloxicam	Drug Info	Approved	Osteoarthritis	ICD11: FA00	[60]
Niraparib	Drug Info	Approved	Ovarian cancer	ICD11: 2C73	[61]
Raltegravir potassium	Drug Info	Approved	Human immunodeficiency virus infection	ICD11: 1C60	[62]
Risdiplam	Drug Info	Approved	Muscular atrophy	ICD11: 8B61	[63]
Risdiplam	Drug Info	Approved	Muscular atrophy	ICD11: 8B61	[64]
Romidepsin	Drug Info	Approved	Cutaneous T-cell lymphoma	ICD11: 2B01	[65]
Testosterone cypionate	Drug Info	Approved	Testosterone deficiency	ICD11: 5A81	[14]
Menadione	Drug Info	Approved	Vitamin deficiency	ICD11: 5B55	[66]
Riboflavin	Drug Info	Approved	Acne vulgaris	ICD11: ED80	[67]
Drugs in Phase 4 Clinical Trial			Click to Show/Hide the Full List of Drugs: 8 Drugs
Cinnarizine	Drug Info	Phase 4	Haemorrhagic stroke	ICD11: 8B20	[1]
Amodiaquine	Drug Info	Phase 4	Malaria	ICD11: 1F40	[68]
Melatonin	Drug Info	Phase 4	Foetal growth restriction	ICD11: KA20	[69]
Zotepine	Drug Info	Phase 4	Schizophrenia	ICD11: 6A20	[70]
Phenacetin	Drug Info	Phase 4	Anaesthesia	ICD11: 8E22	[71]
Flunarizine	Drug Info	Phase 4	Schizophrenia	ICD11: 6A20	[52]
Perazine	Drug Info	Phase 4	Cerebrovascular dementia	ICD11: 6D81	[72]
Retigabine	Drug Info	Phase 4	Epilepsy	ICD11: 8A60	[73]
Drugs in Phase 3 Clinical Trial			Click to Show/Hide the Full List of Drugs: 8 Drugs
E-3A	Drug Info	Phase 3	Turner syndrome	ICD11: LD50	[74]
Finerenone	Drug Info	Phase 3	Diabetic nephropathy	ICD11: GB61	[75]
Finerenone	Drug Info	Phase 3	Diabetic nephropathy	ICD11: GB61	[76]
NE-10064	Drug Info	Phase 3	Cardiac arrhythmia	ICD11: BC65	[77]
NSC-122758	Drug Info	Phase 3	Vitamin deficiency	ICD11: 5B55	[78], [79]
MLN4924	Drug Info	Phase 3	Myelodysplastic syndrome	ICD11: 2A37	[80]
HSDB-3466	Drug Info	Phase 3	Psoriasis vulgaris	ICD11: EA90	[81]
MK-595	Drug Info	Phase 3	Congenital heart anomaly	ICD11: LA8Z	[82]
Drugs in Phase 2 Clinical Trial			Click to Show/Hide the Full List of Drugs: 12 Drugs
CS-5245	Drug Info	Phase 2/3	Fragile X syndrome	ICD11: LD55	[83]
Leniolisib	Drug Info	Phase 2	Sjogren syndrome	ICD11: 4A43	[84]
LIK-066	Drug Info	Phase 2	Heart failure	ICD11: BD10-BD1Z	[85]
BS-3952	Drug Info	Phase 2	Essential hypertension	ICD11: BA00	[86]
AR-67	Drug Info	Phase 2	Brain cancer	ICD11: 2A00	[87]
JI-101	Drug Info	Phase 2	Solid tumour/cancer	ICD11: 2A00-2F9Z	[88]
NAB-365	Drug Info	Phase 2	Amyotrophic lateral sclerosis	ICD11: 8B60	[89]
SMT-C1100	Drug Info	Phase 2	Muscular dystrophy	ICD11: 8C70	[90]
NSC-603071	Drug Info	Phase 2	Ovarian cancer	ICD11: 2C73	[91]
NSC-659853	Drug Info	Phase 2	Breast cancer	ICD11: 2C60	[92]
RG-7916	Drug Info	Phase 2	Muscular atrophy	ICD11: 8B61
SHR-1020	Drug Info	Phase 2	Breast cancer	ICD11: 2C60	[93]
Drugs in Phase 1 Clinical Trial			Click to Show/Hide the Full List of Drugs: 7 Drugs
CB-3304	Drug Info	Phase 1/2	Chronic lymphocytic leukaemia	ICD11: 2A82	[94]
CCRIS-1920	Drug Info	Phase 1/2	Osteoporosis	ICD11: FB83	[95]
TMC-120	Drug Info	Phase 1/2	Human immunodeficiency virus infection	ICD11: 1C60	[96]
Daniquidone	Drug Info	Phase 1	Lymphoma	ICD11: 2A80-2A86	[97]
M-813	Drug Info	Phase 1	Schizophrenia	ICD11: 6A20	[98], [99]
Benzoylphenylurea	Drug Info	Phase 1	Solid tumour/cancer	ICD11: 2A00-2F9Z	[100], [101]
GTPL-1666	Drug Info	Phase 1	Cerebral vasospasm	ICD11: BA85	[102]
Discontinued/withdrawn Drugs			Click to Show/Hide the Full List of Drugs: 7 Drugs
Motesanib	Drug Info	Discontinued in Phase 3	Lung cancer	ICD11: 2C25	[103]
Almokalant	Drug Info	Discontinued in Phase 3	Cardiac arrhythmias	ICD11: BC9Z	[104]
EM-800	Drug Info	Discontinued in Phase 3	Osteoporosis	ICD11: FB83	[105]
YM-992	Drug Info	Discontinued in Phase 2	Depression	ICD11: 6A70-6A7Z	[106]
Tr-14035	Drug Info	Discontinued in Phase 1	Multiple sclerosis	ICD11: 8A40	[107]
CAM-2028	Drug Info	Discontinued	Acute nasopharyngitis	ICD11: CA00	[108]
AN-16649	Drug Info	Discontinued	Acute lymphoblastic leukemia	ICD11: 2B33	[109], [110], [111]
Preclinical/investigative Agents			Click to Show/Hide the Full List of Drugs: 6 Drugs
Coumarin	Drug Info	Investigative	Discovery agent	ICD: N.A.	[112]
Nitrobenzanthrone	Drug Info	Investigative	Discovery agent	ICD: N.A.	[113]
Sudan I	Drug Info	Investigative	Discovery agent	ICD: N.A.	[114]
Acriflavinium chloride	Drug Info	Investigative	Trypanosomiasis	ICD11: 1F51	[115]
Equilenin	Drug Info	Investigative	Discovery agent	ICD: N.A.	[116]
O-Benzylguanine	Drug Info	Investigative	Discovery agent	ICD: N.A.	[117]

Full List of Metabolic Reactions (MR) Catalyzed by This DME

MR ID	Reactant	Product	MR Type	Source Drug	REF
MR009661	AD-5423	N-desethyl blonanserin	Oxidation - N-deethylation	AD-5423	[118]
MR009664	AD-5423	Blonanserin M5	Oxidation - Hydroxylation	AD-5423	[119]
MR009666	AD-5423	Blonanserin M7	Oxidation - Hydroxylation	AD-5423	[119]
MR009668	AD-5423	N-oxidation blonanserin	Oxidation - N-oxidation	AD-5423	[119]
MR009663	Blonanserin M3	Blonanserin M4	Oxidation - Oxidative deamination	AD-5423	[120]
MR009662	N-desethyl blonanserin	Blonanserin M3	Oxidation - N-deethylation	AD-5423	[120]
MR002988	Alitretinoin	4-oxo-9-cis-retinoic acid	Unclear - Unclear	Alitretinoin	[25]
MR002991	Alitretinoin	4-hydroxy-9-cis-retinoic acid	Unclear - Unclear	Alitretinoin	[25]
MR009416	Almokalant	Almokalant Metabolite M13	Oxidation - Sulfoxidation	Almokalant	[104]
MR009417	Almokalant	Almokalant Metabolite M16	Unclear - Unclear	Almokalant	[104]
MR009419	Almokalant	Almokalant Metabolite M3	Unclear - Unclear	Almokalant	[104]
MR013093	Amiodarone hydrochloride	Mono-N-desethylamiodarone	Oxidation - N-dealkylation	Amiodarone hydrochloride	[121], [122], [123]
MR004542	AN-16649	AQ4	Unclear - Unclear	AN-16649	[109], [110], [111]
MR011561	AR-67	AR-67 hypothesize	Unclear - Unclear	AR-67	[87]
MR010376	Benzoylphenylurea	MmBPU	Oxidation - Desmethylation	Benzoylphenylurea	[100], [101]
MR000466	Bromperidol	4-fluorobenzoyl-propionic acid (FBPA)	Unclear - Unclear	Bromperidol	[124]
MR007381	BS-3952	S-(+)-4-hydroxydebrisoquine	Unclear - Unclear	BS-3952	[86]
MR002818	Capsaicin	Capsaicin metabolite M1	Oxidation - Dehydrogenation	Capsaicin	[18]
MR002819	Capsaicin	Capsaicin metabolite M2	Oxidation - Omega-Hydroxylation	Capsaicin	[18]
MR002820	Capsaicin	Capsaicin metabolite M3	Oxidation - Omega-1-Hydroxylation	Capsaicin	[18]
MR002821	Capsaicin	Capsaicin metabolite M4	Oxidation - Dehydrogenation	Capsaicin	[18]
MR002822	Capsaicin	Capsaicin metabolite M5M7	Oxidation - Hydroxylation	Capsaicin	[18]
MR002823	Capsaicin	Capsaicin metabolite M6	Oxidation - O-Dehydrogenation	Capsaicin	[18]
MR002824	Capsaicin	Capsaicin metabolite M8	Oxidation - N-Dehydrogenation; Oxygenation	Capsaicin	[18]
MR002825	Capsaicin	Capsaicin metabolite M9	Oxidation - N-Dehydrogenation	Capsaicin	[18]
MR000573	Carvedilol	1-hydroxyphenylcarvedilol	Oxidation - 1-Hydroxylation	Carvedilol	[26]
MR000569	Carvedilol	8-hydroxycarbazolylcarvedilol	Oxidation - 8-Hydroxylation	Carvedilol	[26]
MR006088	CB-3304	Hydroxylated metabolite	Oxidation - Hydrolyzationn	CB-3304	[94]
MR006089	CB-3304	Hydroxylated metabolite	Oxidation - Hydrolyzationn	CB-3304	[94]
MR013303	Cinnarizine	Cinnarizine metabolite M1	Unclear - Unclear	Cinnarizine	[1]
MR006587	Clonidine	4-Hydroxyclonidine	Oxidation - 4-hydroxylation	Clonidine	[38]
MR005309	Coumarin	7-Hydroxycoumarin	Oxidation - Hydroxy Aromaticlation	Coumarin	[112], [125]
MR005306	Coumarin	Coumarin 3,4-epoxide	Oxidation - Epoxidation	Coumarin	[112]
MR005311	Coumarin	4-Hydroxycoumarin	Oxidation - Hydrolyzationn	Coumarin	[126]
MR005312	Coumarin	5-Hydroxycoumarin	Oxidation - Hydrolyzationn	Coumarin	[126]
MR005313	Coumarin	6-Hydroxycoumarin	Oxidation - Hydrolyzationn	Coumarin	[126]
MR005314	Coumarin	8-Hydroxycoumarin	Oxidation - Hydrolyzationn	Coumarin	[126]
MR006515	CS-5245	Mavoglurant metabolite M3	Oxidation - Oxidationn	CS-5245	[127]
MR006605	Dacarbazine	5-[3-hydroxymethyl-3-methyl-triazen-1-yl]-imidazole-4-carboxamide (HMMTIC)	Unclear - Unclear	Dacarbazine	[128]
MR002839	Dapagliflozin	Dapagliflozin BMS-511926	Oxidation - O-Deethylation	Dapagliflozin	[129]
MR002840	Dapagliflozin	Dapagliflozin BMS-639432	Oxidation - Hydroxylation	Dapagliflozin	[129]
MR003250	(4RS,5S)-DM-6720	(S)-DM-6718	Unclear - Unclear	Delamanid	[130]
MR003252	Delamanid	(4RS,5S)-DM-6720	Unclear - Unclear	Delamanid	[130]
MR006615	Hydroxilated form of dolutegravir (M3)	2,4- difluorobenzaldehyde (M5 dolutegravir)	Hydrolysis - Hydrolysis	Dolutegravir sodium	[131]
MR006616	Hydroxilated form of dolutegravir (M3)	Hydrolized form of dolutegravir (M1)	Hydrolysis - Hydrolysis	Dolutegravir sodium	[131]
MR013313	E-3A	2-hydroxyestrone	Oxidation - 2-hydroxylation	E-3A	[132]
MR013313	E-3A	2-hydroxyestrone	Oxidation - Aromatic hydroxylation	E-3A	[133]
MR004235	Eqn-17beta	2-OHEqn-17beta	Unclear - Unclear	Equilenin	[116]
MR004234	Equilenin	Eqn-17beta	Oxidation - 4-hydroxylation	Equilenin	[116]
MR003018	Erlotinib hydrochloride	Erlotinib M14	Oxidation - O-demethylation	Erlotinib hydrochloride	[4], [134]
MR003007	Erlotinib M2	Erlotinib M14	Oxidation - O-demethylation	Erlotinib hydrochloride	[4], [134]
MR002625	Estradiol	2-hydroxyestrone	Oxidation - 2-Hydroxylation	Estradiol acetate	[135], [136]
MR002625	Estradiol	2-hydroxyestrone	Oxidation - Hydroxylation	Estradiol acetate	[136]
MR002648	Estradiol	2-hydroxyestrone	Oxidation - Hydroxylation	Estradiol cypionate	[135], [136]
MR002648	Estradiol	2-hydroxyestrone	Oxidation - 2-Hydroxylation	Estradiol cypionate	[136]
MR002671	Estradiol	2-hydroxyestrone	Oxidation - Hydroxylation	Estradiol valerate	[135], [136]
MR002671	Estradiol	2-hydroxyestrone	Oxidation - 2-Hydroxylation	Estradiol valerate	[136]
MR002701	Estrone	4-OH-estrone	Oxidation - Hydroxylation	Estrone	[4]
MR002706	Estrone	16alpha-OH-estrone	Oxidation - Hydroxylation	Estrone	[4]
MR002702	Estrone	6alpha-OH-estrone	Oxidation - Hydroxylation	Estrone	[4]
MR002705	Estrone	15alpha-OH-estrone	Unclear - Unclear	Estrone	[4]
MR002704	Estrone	7alpha-OH-estrone	Unclear - Unclear	Estrone	[4]
MR003400	Febuxostat	Febuxostat metabolite 67M-2	Oxidation - Oxidation	Febuxostat	[137]
MR003401	Febuxostat	Febuxostat metabolite 67M-3	Oxidation - Oxidation	Febuxostat	[137]
MR013905	Flunarizine	Flunarizine M1	Oxidation - N-desalkylation	Flunarizine	[1]
MR013907	Flunarizine	Flunarizine M3	Oxidation - N-desalkylation	Flunarizine	[1]
MR001063	Fluvastatin sodium	5-hydroxyfluvastatin	Oxidation - 5-Hydroxylation	Fluvastatin sodium	[1], [138]
MR001115	Gefitinib	Metabolism of the N-propoxymorpholino-group	Unclear - Unclear	Gefitinib	[139]
MR001117	Gefitinib	Oxidative defluorination of the halogenated phenyl group	Oxidation - Oxidative Defluorination	Gefitinib	[139]
MR001152	Granisetron hydrochloride	9'-desmethylgranisetron	Oxidation - Demethylation	Granisetron hydrochloride	[140]
MR001153	Granisetron hydrochloride	7-hydroxygranisetron	Oxidation - Hydoxylation	Granisetron hydrochloride	[140]
MR004669	Imatinib mesylate	N-Desmethylimatinib	Oxidation - N-demethylation	Imatinib mesylate	[1], [15], [16]
MR004670	Imatinib mesylate	AFN911	Oxidation - Benzyl hydroxylation	Imatinib mesylate	[16]
MR004673	Imatinib mesylate	M7 N-oxidation imatinib	Oxidation - N-oxidation	Imatinib mesylate	[16]
MR012487	JI-101	JI-101 M1	Oxidation - Dihydroxylation	JI-101	[88]
MR010933	Lenvatinib	O-demethyl Lenvatinib	Unclear - Unclear	Lenvatinib	[46]
MR003108	Lesinurad	Lesinurad metabolite M3	Oxidation - Hydroxylation	Lesinurad	[34]
MR005376	Levoverbenone	(-)-10-OH Verbenone	Oxidation - Hydrolyzationn	Levoverbenone	[141]
MR012306	LIK-066	LIK-066 M13,14	Oxidation - Oxidation	LIK-066	[85]
MR006901	Loratadine	Desloratadine	Oxidation - Oxidationn	Loratadine	[142]
MR006906	Lorcaserin	N-hydroxylorcaserin	Oxidation - Hydrolyzationn	Lorcaserin	[143]
MR006908	Lorcaserin	5-Hydroxylorcaserin	Oxidation - Hydrolyzationn	Lorcaserin	[143]
MR006926	Loxapine succinate	7-Hydroxyloxapine	Oxidation - Oxidationn	Loxapine succinate	[39]
MR006927	Loxapine succinate	Amoxapine	Oxidation - Oxidationn	Loxapine succinate	[39]
MR013356	Hydroxyperospirone	M-813 Metabolite MX11	Unclear - Unclear	M-813	[99], [144]
MR013367	ID-15010	M-813 Metabolite MX6	Unclear - Unclear	M-813	[99]
MR013363	M-813	M-813 Metabolite MX1	Unclear - Unclear	M-813	[144], [99]
MR013355	M-813	Hydroxyperospirone	Oxidation - Hydrolyzationn	M-813	[98], [99]
MR013365	M-813	ID-11614	Unclear - Unclear	M-813	[99]
MR013366	M-813	ID-15010	Unclear - Unclear	M-813	[99]
MR013440	Maprotiline hydrochloride	2-OH-maprotiline	Oxidation - Aromatic hydroxylation	Maprotiline hydrochloride	[4]
MR003317	Melatonin	6-hydroxymelatonin	Oxidation - 6-Hydroxylation	Melatonin	[1]
MR002857	Meloxicam	5-hydroxymethyl meloxicam	Oxidation - Hydroxylation	Meloxicam	[145], [60]
MR011622	MLN4924	MLN4924 Metabolite M1	Oxidation - Hydroxylation	MLN4924	[80]
MR011624	MLN4924	MLN4924 Metabolite M3	Oxidation - Hydroxylation	MLN4924	[80]
MR009723	Motesanib	Motesanib M5	Oxidation - Hydroxylation	Motesanib	[103]
MR009726	Motesanib	Motesanib M4	Unclear - Unclear	Motesanib	[103], [146]
MR009732	Motesanib	Motesanib M3	Unclear - Unclear	Motesanib	[103]
MR003784	NE-10064	NE-10064 Metabolite M2	Unclear - Unclear	NE-10064	[77]
MR001730	Nicardipine hydrochloride	Dehydronicardipine	Oxidation - Heteroring Dehydrogenation	Nicardipine hydrochloride	[136], [36], [147]
MR003537	Nintedanib esylate	Nintedanib metabolite M5	Oxidation - Demethylation	Nintedanib esylate	[148]
MR004363	Nitrobenzanthrone	3-OH-ABA	Reduction - Reduction	Nitrobenzanthrone	[149]
MR006380	NSC-122758	4-Hydroxyretinoic acid	Oxidation - 4-hydroxylation	NSC-122758	[78]
MR001797	9-Aminocamptothecin metabolite M2	9-Aminocamptothecin metabolite M1	Unclear - Unclear	NSC-603071	[91]
MR001798	NSC-603071	9-Aminocamptothecin metabolite M2	Unclear - Unclear	NSC-603071	[91]
MR004429	6-O-benzyl-8-oxoguanine	8-oxoguanine	Oxidation - Debenzylation	O-Benzylguanine	[117]
MR004428	O-Benzylguanine	6-O-benzyl-8-oxoguanine	Oxidation - Oxidationn	O-Benzylguanine	[117]
MR001972	Pentamidine isethionate	Pentamidine Amidoxime	Oxidation - N-Hydroxylation	Pentamidine isethionate	[150], [151]
MR001972	Pentamidine isethionate	Pentamidine Amidoxime	Oxidation - N-Hydroxylation	Pentamidine isethionate	[150], [151]
MR002013	Acetaminophen	Acetaminophen sulfate	Unclear - Unclear	Phenacetin	[152]
MR002010	Phenacetin	N-OH-phenacetin	Oxidation - N-Oxidation	Phenacetin	[152]
MR002165	Procarbazine	Azoprocarbazine	Unclear - Unclear	Procarbazine	[153], [154]
MR013648	PT2385	PT2385 M10	Oxidation - Hydroxylation	PT2385	[155]
MR013646	PT2385	PT2385 M2	Oxidation - Hydroxylation	PT2385	[155]
MR009542	Riluzole	N-OH-riluzole	Oxidation - N-oxidation	Riluzole	[4]
MR009539	Riluzole	4-OH-riluzole	Oxidation - Aromatic hydroxylation	Riluzole	[4]
MR009540	Riluzole	5-OH-riluzole	Oxidation - Aromatic hydroxylation	Riluzole	[4]
MR009541	Riluzole	7-OH-riluzole	Oxidation - Aromatic hydroxylation	Riluzole	[4]
MR009543	Riluzole	2-Amino-6-OH-benzothiazole	Unclear - Unclear	Riluzole	[4]
MR009544	Riociguat	Riociguat metabolite M1	Oxidation - N-demethylation	Riociguat	[156], [157]
MR005593	Risdiplam	Risdiplam M1 metabolite	Oxidation - N-hydroxylation	Risdiplam	[63]
MR006596	Romidepsin	Romidepsin metabolite M1	Reduction - Reduction	Romidepsin	[65]
MR008502	SMT-C1100	DHD1	Unclear - Unclear	SMT-C1100	[90]
MR008503	SMT-C1100	DHD3	Unclear - Unclear	SMT-C1100	[90]
MR006826	Solifenacin succinate	4R-hydroxy solifenacin	Oxidation - Hydrolyzationn	Solifenacin succinate	[41]
MR005894	Sudan I	Unclear	Unclear - Unclear	Sudan I	[114]
MR008084	Sulindac	Sulindac sulfone	Oxidation - Oxidation	Sulindac	[56]
MR008647	Sunitinib malate	Sunitinib malate Metabolite M8	Reduction - Reduction	Sunitinib malate	[158], [20]
MR003510	Tamoxifen citrate	N-Desmethyltamoxifen	Oxidation - N-Dealkylation	Tamoxifen citrate	[3], [159], [160], [161], [162]
MR002342	Tasimelteon	Inosine	Oxidation - Hydroxylation	Tasimelteon	[163]
MR004939	Thalidomide	Thalidomide arene oxide	Oxidation - Epoxidation	Thalidomide	[1], [2]
MR006149	TMC-120	Unclear	Unclear - Unclear	TMC-120	[96]
MR012215	TR-14081	TR-14331	Oxidation - Di-O-desmethylation	TR-14035	[107]
MR009626	Tretinoin	4-Hydroxyretinoic acid	Oxidation - 4-hydroxylation	Tretinoin	[78], [21]
MR009629	Tretinoin	5,6-epoxy-RA	Oxidation - Ring epoxidation	Tretinoin	[164], [164], [78]
MR002909	TCBZ-SX	Triclabendazole sulfone metabolite	Oxidation - Oxidation	Triclabendazole	[165], [166]
MR013194	Umeclidinium bromide	Umeclidinium M14	Oxidation - O-dealkylation	Umeclidinium bromide	[32]
MR013081	Zotepine	Norzotepine	Oxidation - N-demethylation	Zotepine	[4], [167]
MR013084	Zotepine	3-OH-zotepine	Oxidation - Aromatic hydroxylation	Zotepine	[4]
MR013085	Zotepine	Zotepine S-oxide	Oxidation - S-oxidation	Zotepine	[4]


⏷ Show the Full List of 140 MR(s)

Tissue/Disease-Specific Protein Abundances of This DME
Tissue-specific Protein Abundances in Healthy Individuals		Click to Show/Hide

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ICD Disease Classification 01	Infectious/parasitic disease	Click to Show/Hide
ICD-11: 1C1H	Necrotising ulcerative gingivitis	Click to Show/Hide
The Studied Tissue	Gingival tissue
The Specified Disease	Bacterial infection of gingival [ICD-11:1C1H]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 6.86E-05; Fold-change: 1.01E-01; Z-score: 4.55E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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ICD-11: 1E30	Influenza	Click to Show/Hide
The Studied Tissue	Whole blood
The Specified Disease	Influenza [ICD-11:1E30]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.04E-01; Fold-change: 2.59E-02; Z-score: 2.94E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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ICD-11: 1E51	Chronic viral hepatitis	Click to Show/Hide
The Studied Tissue	Whole blood
The Specified Disease	Chronic hepatitis C [ICD-11:1E51.1]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.24E-01; Fold-change: 7.47E-02; Z-score: 2.73E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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ICD-11: 1G41	Sepsis with septic shock	Click to Show/Hide
The Studied Tissue	Whole blood
The Specified Disease	Sepsis with septic shock [ICD-11:1G41]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.55E-09; Fold-change: 1.64E-01; Z-score: 6.56E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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ICD-11: CA40	Respiratory syncytial virus infection	Click to Show/Hide
The Studied Tissue	Peripheral blood
The Specified Disease	Pediatric respiratory syncytial virus infection [ICD-11:CA40.11]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.30E-01; Fold-change: -5.57E-03; Z-score: -3.08E-02
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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ICD-11: CA42	Rhinovirus infection	Click to Show/Hide
The Studied Tissue	Nasal epithelium tissue
The Specified Disease	Rhinovirus infection [ICD-11:CA42.1]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 6.79E-01; Fold-change: -1.94E-02; Z-score: -2.31E-02
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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ICD-11: KA60	Neonatal sepsis	Click to Show/Hide
The Studied Tissue	Whole blood
The Specified Disease	Neonatal sepsis [ICD-11:KA60]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 3.28E-02; Fold-change: 6.59E-02; Z-score: 2.63E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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ICD Disease Classification 02	Neoplasm	Click to Show/Hide
ICD-11: 2A00	Brain cancer	Click to Show/Hide
The Studied Tissue	Nervous tissue
The Specified Disease	Glioblastopma [ICD-11:2A00.00]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 5.48E-47; Fold-change: -3.01E-01; Z-score: -8.32E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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The Studied Tissue	Brain stem tissue
The Specified Disease	Glioma [ICD-11:2A00.0Y-2A00.0Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 9.90E-01; Fold-change: -3.64E-02; Z-score: -1.18E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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The Studied Tissue	White matter tissue
The Specified Disease	Glioma [ICD-11:2A00.0Y-2A00.0Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.46E-02; Fold-change: 9.11E-02; Z-score: 1.61E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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The Studied Tissue	Brain stem tissue
The Specified Disease	Neuroectodermal tumour [ICD-11:2A00.11]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.22E-03; Fold-change: -6.41E-01; Z-score: -1.80E+00
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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ICD-11: 2A20	Myeloproliferative neoplasm	Click to Show/Hide
The Studied Tissue	Whole blood
The Specified Disease	Myelofibrosis [ICD-11:2A20.2]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 5.59E-03; Fold-change: 1.79E-01; Z-score: 1.05E+00
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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The Studied Tissue	Whole blood
The Specified Disease	Polycythemia vera [ICD-11:2A20.4]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.43E-12; Fold-change: 3.21E-01; Z-score: 1.69E+00
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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ICD-11: 2A36	Myelodysplastic syndrome	Click to Show/Hide
The Studied Tissue	Bone marrow
The Specified Disease	Myelodysplastic syndrome [ICD-11:2A36-2A3Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.93E-01; Fold-change: -4.38E-03; Z-score: -9.40E-03
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 1.31E-01; Fold-change: -1.64E-01; Z-score: -1.87E+00
DME expression in the diseased tissue of patients DME expression in the normal tissue adjacent to the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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ICD-11: 2A81	Diffuse large B-cell lymphoma	Click to Show/Hide
The Studied Tissue	Tonsil tissue
The Specified Disease	Diffuse large B-cell lymphoma [ICD-11:2A81]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 3.93E-01; Fold-change: -1.05E-01; Z-score: -2.24E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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ICD-11: 2A83	Plasma cell neoplasm	Click to Show/Hide
The Studied Tissue	Peripheral blood
The Specified Disease	Multiple myeloma [ICD-11:2A83.1]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.33E-01; Fold-change: 1.26E-01; Z-score: 3.83E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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The Studied Tissue	Bone marrow
The Specified Disease	Multiple myeloma [ICD-11:2A83.1]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.72E-02; Fold-change: -1.97E-01; Z-score: -8.12E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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ICD-11: 2B33	Leukaemia	Click to Show/Hide
The Studied Tissue	Bone marrow
The Specified Disease	Acute myelocytic leukaemia [ICD-11:2B33.1]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.37E-01; Fold-change: -9.49E-02; Z-score: -3.91E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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ICD-11: 2B6E	Oral cancer	Click to Show/Hide
The Studied Tissue	Oral tissue
The Specified Disease	Oral cancer [ICD-11:2B6E]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.45E-03; Fold-change: -2.74E-01; Z-score: -2.72E-01
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 5.56E-03; Fold-change: 1.02E-01; Z-score: 3.44E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue adjacent to the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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ICD-11: 2B70	Esophageal cancer	Click to Show/Hide
The Studied Tissue	Esophagus
The Specified Disease	Esophagal cancer [ICD-11:2B70]
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 3.21E-01; Fold-change: -1.18E-01; Z-score: -1.83E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue adjacent to the diseased tissue of patients
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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ICD-11: 2B72	Stomach cancer	Click to Show/Hide
The Studied Tissue	Gastric tissue
The Specified Disease	Gastric cancer [ICD-11:2B72]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.75E-02; Fold-change: -6.33E-01; Z-score: -2.13E+00
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 6.40E-01; Fold-change: -1.99E-02; Z-score: -6.21E-02
DME expression in the diseased tissue of patients DME expression in the normal tissue adjacent to the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data of patients in the normal section of the tissue adjacent to the disease section Download DME expression data in the tissue of healthy individual
ICD-11: 2B90	Colon cancer	Click to Show/Hide
The Studied Tissue	Colon tissue
The Specified Disease	Colon cancer [ICD-11:2B90]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.62E-03; Fold-change: -8.29E-02; Z-score: -1.75E-01
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 8.43E-04; Fold-change: -1.18E-01; Z-score: -3.71E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue adjacent to the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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ICD-11: 2B92	Rectal cancer	Click to Show/Hide
The Studied Tissue	Rectal colon tissue
The Specified Disease	Rectal cancer [ICD-11:2B92]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 7.71E-01; Fold-change: -2.82E-02; Z-score: -1.18E-01
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 2.10E-01; Fold-change: -2.84E-01; Z-score: -8.26E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue adjacent to the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data of patients in the normal section of the tissue adjacent to the disease section Download DME expression data in the tissue of healthy individual
ICD-11: 2C10	Pancreatic cancer	Click to Show/Hide
The Studied Tissue	Pancreas
The Specified Disease	Pancreatic cancer [ICD-11:2C10]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.38E-04; Fold-change: -3.36E-01; Z-score: -1.19E+00
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 3.89E-02; Fold-change: -2.29E-01; Z-score: -2.85E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue adjacent to the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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ICD-11: 2C12	Liver cancer	Click to Show/Hide
The Studied Tissue	Liver tissue
The Specified Disease	Liver cancer [ICD-11:2C12.0]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.48E-09; Fold-change: -2.66E+00; Z-score: -2.18E+00
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 2.14E-17; Fold-change: -1.94E+00; Z-score: -1.60E+00
The Expression Level of Disease Section Compare with the Other Disease Section	p-value: 1.10E-04; Fold-change: -2.18E+00; Z-score: -7.89E+00
DME expression in the diseased tissue of patients DME expression in the normal tissue adjacent to the diseased tissue of patients DME expression in the normal tissue of healthy individuals DME expression in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data of patients in the normal section of the tissue adjacent to the disease section Download DME expression data in the tissue of healthy individual Download DME expression data in the tissue of the other disease section
ICD-11: 2C25	Lung cancer	Click to Show/Hide
The Studied Tissue	Lung tissue
The Specified Disease	Lung cancer [ICD-11:2C25]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.99E-02; Fold-change: -3.84E-03; Z-score: -3.55E-03
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 6.88E-01; Fold-change: -5.96E-02; Z-score: -1.38E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue adjacent to the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data of patients in the normal section of the tissue adjacent to the disease section Download DME expression data in the tissue of healthy individual
ICD-11: 2C30	Skin cancer	Click to Show/Hide
The Studied Tissue	Skin
The Specified Disease	Melanoma [ICD-11:2C30]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.74E-01; Fold-change: 5.66E-02; Z-score: 5.84E-02
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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The Studied Tissue	Skin
The Specified Disease	Skin cancer [ICD-11:2C30-2C3Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.66E-11; Fold-change: -4.25E-01; Z-score: -2.87E-01
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 8.52E-03; Fold-change: -7.65E-02; Z-score: -6.02E-02
DME expression in the diseased tissue of patients DME expression in the normal tissue adjacent to the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data of patients in the normal section of the tissue adjacent to the disease section Download DME expression data in the tissue of healthy individual
ICD-11: 2C6Z	Breast cancer	Click to Show/Hide
The Studied Tissue	Breast tissue
The Specified Disease	Breast cancer [ICD-11:2C60-2C6Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 5.28E-09; Fold-change: -1.55E-01; Z-score: -1.78E-01
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 4.62E-02; Fold-change: -6.17E-02; Z-score: -1.01E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue adjacent to the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data of patients in the normal section of the tissue adjacent to the disease section Download DME expression data in the tissue of healthy individual
ICD-11: 2C73	Ovarian cancer	Click to Show/Hide
The Studied Tissue	Ovarian tissue
The Specified Disease	Ovarian cancer [ICD-11:2C73]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 5.71E-01; Fold-change: -1.43E-01; Z-score: -5.46E-01
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 8.98E-01; Fold-change: -2.54E-02; Z-score: -7.86E-02
DME expression in the diseased tissue of patients DME expression in the normal tissue adjacent to the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data of patients in the normal section of the tissue adjacent to the disease section Download DME expression data in the tissue of healthy individual
ICD-11: 2C77	Cervical cancer	Click to Show/Hide
The Studied Tissue	Cervical tissue
The Specified Disease	Cervical cancer [ICD-11:2C77]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 7.17E-01; Fold-change: -1.72E-02; Z-score: -5.33E-02
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 2C78	Uterine cancer	Click to Show/Hide
The Studied Tissue	Endometrium tissue
The Specified Disease	Uterine cancer [ICD-11:2C78]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.46E-01; Fold-change: -7.08E-03; Z-score: -2.10E-02
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 1.83E-01; Fold-change: -2.45E-01; Z-score: -4.13E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue adjacent to the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data of patients in the normal section of the tissue adjacent to the disease section Download DME expression data in the tissue of healthy individual
ICD-11: 2C82	Prostate cancer	Click to Show/Hide
The Studied Tissue	Prostate
The Specified Disease	Prostate cancer [ICD-11:2C82]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 3.83E-02; Fold-change: -4.91E-01; Z-score: -4.02E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 2C90	Renal cancer	Click to Show/Hide
The Studied Tissue	Kidney
The Specified Disease	Renal cancer [ICD-11:2C90-2C91]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.34E-04; Fold-change: -6.01E-01; Z-score: -1.73E+00
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 3.55E-16; Fold-change: -4.34E-01; Z-score: -1.31E+00
DME expression in the diseased tissue of patients DME expression in the normal tissue adjacent to the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data of patients in the normal section of the tissue adjacent to the disease section Download DME expression data in the tissue of healthy individual
ICD-11: 2C92	Ureter cancer	Click to Show/Hide
The Studied Tissue	Urothelium
The Specified Disease	Ureter cancer [ICD-11:2C92]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 9.34E-01; Fold-change: -1.74E-01; Z-score: -3.73E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 2C94	Bladder cancer	Click to Show/Hide
The Studied Tissue	Bladder tissue
The Specified Disease	Bladder cancer [ICD-11:2C94]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 3.08E-03; Fold-change: -2.68E+00; Z-score: -2.11E+00
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 2D02	Retinal cancer	Click to Show/Hide
The Studied Tissue	Uvea
The Specified Disease	Retinoblastoma [ICD-11:2D02.2]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 5.40E-02; Fold-change: -2.03E-01; Z-score: -1.83E+00
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 2D10	Thyroid cancer	Click to Show/Hide
The Studied Tissue	Thyroid
The Specified Disease	Thyroid cancer [ICD-11:2D10]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.13E-02; Fold-change: 4.75E-02; Z-score: 1.99E-01
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 4.14E-01; Fold-change: 1.22E-01; Z-score: 3.45E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue adjacent to the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data of patients in the normal section of the tissue adjacent to the disease section Download DME expression data in the tissue of healthy individual
ICD-11: 2D11	Adrenal cancer	Click to Show/Hide
The Studied Tissue	Adrenal cortex
The Specified Disease	Adrenocortical carcinoma [ICD-11:2D11.Z]
The Expression Level of Disease Section Compare with the Other Disease Section	p-value: 1.17E-01; Fold-change: -7.18E-03; Z-score: -1.57E-02
DME expression in the diseased tissue of patients DME expression in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of the other disease section
ICD-11: 2D12	Endocrine gland neoplasm	Click to Show/Hide
The Studied Tissue	Pituitary tissue
The Specified Disease	Pituitary cancer [ICD-11:2D12]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.55E-02; Fold-change: 2.48E-01; Z-score: 7.63E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
The Studied Tissue	Pituitary tissue
The Specified Disease	Pituitary gonadotrope tumour [ICD-11:2D12]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.31E-01; Fold-change: 1.19E-01; Z-score: 3.91E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 2D42	Head and neck cancer	Click to Show/Hide
The Studied Tissue	Head and neck tissue
The Specified Disease	Head and neck cancer [ICD-11:2D42]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.33E-03; Fold-change: -1.84E-02; Z-score: -1.02E-02
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD Disease Classification 03	Blood/blood-forming organ disease	Click to Show/Hide
ICD-11: 3A51	Sickle cell disorder	Click to Show/Hide
The Studied Tissue	Peripheral blood
The Specified Disease	Sickle cell disease [ICD-11:3A51.0-3A51.3]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.92E-01; Fold-change: 2.74E-01; Z-score: 4.93E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 3A70	Aplastic anaemia	Click to Show/Hide
The Studied Tissue	Bone marrow
The Specified Disease	Shwachman-Diamond syndrome [ICD-11:3A70.0]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.86E-01; Fold-change: 3.91E-01; Z-score: 8.45E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 3B63	Thrombocytosis	Click to Show/Hide
The Studied Tissue	Whole blood
The Specified Disease	Thrombocythemia [ICD-11:3B63]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.69E-04; Fold-change: 2.49E-01; Z-score: 1.39E+00
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 3B64	Thrombocytopenia	Click to Show/Hide
The Studied Tissue	Whole blood
The Specified Disease	Thrombocytopenia [ICD-11:3B64]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 7.49E-01; Fold-change: 0.00E+00; Z-score: 0.00E+00
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD Disease Classification 04	Immune system disease	Click to Show/Hide
ICD-11: 4A00	Immunodeficiency	Click to Show/Hide
The Studied Tissue	Peripheral blood
The Specified Disease	Immunodeficiency [ICD-11:4A00-4A20]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 7.54E-01; Fold-change: 7.57E-02; Z-score: 9.05E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 4A40	Lupus erythematosus	Click to Show/Hide
The Studied Tissue	Whole blood
The Specified Disease	Lupus erythematosus [ICD-11:4A40]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.79E-02; Fold-change: -8.23E-02; Z-score: -1.08E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 4A42	Systemic sclerosis	Click to Show/Hide
The Studied Tissue	Whole blood
The Specified Disease	Scleroderma [ICD-11:4A42.Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.88E-02; Fold-change: -1.27E-01; Z-score: -9.50E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 4A43	Systemic autoimmune disease	Click to Show/Hide
The Studied Tissue	Salivary gland tissue
The Specified Disease	Sjogren's syndrome [ICD-11:4A43.2]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.53E-01; Fold-change: -5.22E-02; Z-score: -1.69E-01
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 6.20E-02; Fold-change: -1.05E+00; Z-score: -1.62E+00
DME expression in the diseased tissue of patients DME expression in the normal tissue adjacent to the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data of patients in the normal section of the tissue adjacent to the disease section Download DME expression data in the tissue of healthy individual
ICD-11: 4A62	Behcet disease	Click to Show/Hide
The Studied Tissue	Peripheral blood
The Specified Disease	Behcet's disease [ICD-11:4A62]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 5.27E-01; Fold-change: -3.43E-02; Z-score: -2.24E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 4B04	Monocyte count disorder	Click to Show/Hide
The Studied Tissue	Whole blood
The Specified Disease	Autosomal dominant monocytopenia [ICD-11:4B04]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 3.61E-01; Fold-change: 4.78E-02; Z-score: 2.17E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD Disease Classification 05	Endocrine/nutritional/metabolic disease	Click to Show/Hide
ICD-11: 5A11	Type 2 diabetes mellitus	Click to Show/Hide
The Studied Tissue	Omental adipose tissue
The Specified Disease	Obesity related type 2 diabetes [ICD-11:5A11]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.25E-01; Fold-change: 1.91E-01; Z-score: 6.80E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
The Studied Tissue	Liver tissue
The Specified Disease	Type 2 diabetes [ICD-11:5A11]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 6.63E-01; Fold-change: 3.55E-01; Z-score: 4.13E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 5A80	Ovarian dysfunction	Click to Show/Hide
The Studied Tissue	Vastus lateralis muscle
The Specified Disease	Polycystic ovary syndrome [ICD-11:5A80.1]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.67E-01; Fold-change: 7.63E-03; Z-score: 2.91E-02
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 5C51	Inborn carbohydrate metabolism disorder	Click to Show/Hide
The Studied Tissue	Biceps muscle
The Specified Disease	Pompe disease [ICD-11:5C51.3]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 6.86E-01; Fold-change: -3.43E-02; Z-score: -1.84E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 5C56	Lysosomal disease	Click to Show/Hide
The Studied Tissue	Whole blood
The Specified Disease	Batten disease [ICD-11:5C56.1]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 3.47E-01; Fold-change: 1.69E-02; Z-score: 1.33E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 5C80	Hyperlipoproteinaemia	Click to Show/Hide
The Studied Tissue	Peripheral blood
The Specified Disease	Familial hypercholesterolemia [ICD-11:5C80.00]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.98E-02; Fold-change: 1.50E-01; Z-score: 2.10E+00
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
The Studied Tissue	Whole blood
The Specified Disease	Familial hypercholesterolemia [ICD-11:5C80.00]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 7.09E-03; Fold-change: -2.38E-01; Z-score: -7.72E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
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ICD Disease Classification 06	Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
ICD-11: 6A02	Autism spectrum disorder	Click to Show/Hide
The Studied Tissue	Whole blood
The Specified Disease	Autism [ICD-11:6A02]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.25E-01; Fold-change: -1.10E-01; Z-score: -4.94E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 6A20	Schizophrenia	Click to Show/Hide
The Studied Tissue	Prefrontal cortex
The Specified Disease	Schizophrenia [ICD-11:6A20]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.32E-01; Fold-change: -3.66E-02; Z-score: -1.30E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
The Studied Tissue	Superior temporal cortex
The Specified Disease	Schizophrenia [ICD-11:6A20]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 6.55E-01; Fold-change: 1.27E-02; Z-score: 8.44E-02
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 6A60	Bipolar disorder	Click to Show/Hide
The Studied Tissue	Prefrontal cortex
The Specified Disease	Bipolar disorder [ICD-11:6A60-6A6Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.16E-01; Fold-change: -9.73E-03; Z-score: -4.11E-02
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 6A70	Depressive disorder	Click to Show/Hide
The Studied Tissue	Whole blood
The Specified Disease	Major depressive disorder [ICD-11:6A70-6A7Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.61E-01; Fold-change: 1.37E-03; Z-score: 5.40E-03
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
The Studied Tissue	Hippocampus
The Specified Disease	Major depressive disorder [ICD-11:6A70-6A7Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 9.33E-01; Fold-change: 3.62E-02; Z-score: 1.51E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD Disease Classification 08	Nervous system disease	Click to Show/Hide
ICD-11: 8A00	Parkinsonism	Click to Show/Hide
The Studied Tissue	Substantia nigra tissue
The Specified Disease	Parkinson's disease [ICD-11:8A00.0]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 7.84E-01; Fold-change: -1.03E-01; Z-score: -4.48E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 8A01	Choreiform disorder	Click to Show/Hide
The Studied Tissue	Whole blood
The Specified Disease	Huntington's disease [ICD-11:8A01.10]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 3.39E-01; Fold-change: -1.41E-01; Z-score: -7.19E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 8A20	Alzheimer disease	Click to Show/Hide
The Studied Tissue	Entorhinal cortex
The Specified Disease	Alzheimer's disease [ICD-11:8A20]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 6.83E-06; Fold-change: -1.42E-01; Z-score: -4.93E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 8A2Y	Neurocognitive impairment	Click to Show/Hide
The Studied Tissue	White matter tissue
The Specified Disease	HIV-associated neurocognitive impairment [ICD-11:8A2Y-8A2Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.24E-01; Fold-change: -1.24E-01; Z-score: -5.62E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 8A40	Multiple sclerosis	Click to Show/Hide
The Studied Tissue	Plasmacytoid dendritic cells
The Specified Disease	Multiple sclerosis [ICD-11:8A40]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 5.01E-01; Fold-change: -1.01E-02; Z-score: -6.05E-02
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
The Studied Tissue	Spinal cord
The Specified Disease	Multiple sclerosis [ICD-11:8A40]
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 1.39E-01; Fold-change: 1.62E-01; Z-score: 9.60E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue adjacent to the diseased tissue of patients
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data of patients in the normal section of the tissue adjacent to the disease section
ICD-11: 8A60	Epilepsy	Click to Show/Hide
The Studied Tissue	Peritumoral cortex tissue
The Specified Disease	Epilepsy [ICD-11:8A60-8A6Z]
The Expression Level of Disease Section Compare with the Other Disease Section	p-value: 2.30E-01; Fold-change: 1.86E-01; Z-score: 1.25E+00
DME expression in the diseased tissue of patients DME expression in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of the other disease section
The Studied Tissue	Whole blood
The Specified Disease	Seizure [ICD-11:8A60-8A6Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.82E-01; Fold-change: 9.24E-03; Z-score: 3.62E-02
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 8B01	Subarachnoid haemorrhage	Click to Show/Hide
The Studied Tissue	Intracranial artery
The Specified Disease	Intracranial aneurysm [ICD-11:8B01.0]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 9.97E-02; Fold-change: -2.81E-01; Z-score: -7.92E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 8B11	Cerebral ischaemic stroke	Click to Show/Hide
The Studied Tissue	Whole blood
The Specified Disease	Cardioembolic stroke [ICD-11:8B11.20]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 5.24E-02; Fold-change: 2.60E-02; Z-score: 1.93E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
The Studied Tissue	Peripheral blood
The Specified Disease	Ischemic stroke [ICD-11:8B11]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.00E-01; Fold-change: 1.96E-02; Z-score: 1.29E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 8B60	Motor neuron disease	Click to Show/Hide
The Studied Tissue	Skin
The Specified Disease	Lateral sclerosis [ICD-11:8B60.4]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.86E-01; Fold-change: 3.14E-02; Z-score: 8.69E-02
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
The Studied Tissue	Cervical spinal cord
The Specified Disease	Lateral sclerosis [ICD-11:8B60.4]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.89E-01; Fold-change: 1.53E-01; Z-score: 9.88E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 8C70	Muscular dystrophy	Click to Show/Hide
The Studied Tissue	Muscle tissue
The Specified Disease	Myopathy [ICD-11:8C70.6]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 3.18E-02; Fold-change: -5.95E-01; Z-score: -5.76E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: 8C75	Distal myopathy	Click to Show/Hide
The Studied Tissue	Muscle tissue
The Specified Disease	Tibial muscular dystrophy [ICD-11:8C75]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.71E-02; Fold-change: -2.19E-01; Z-score: -1.44E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD Disease Classification 09	Visual system disease	Click to Show/Hide
ICD-11: 9A96	Anterior uveitis	Click to Show/Hide
The Studied Tissue	Peripheral monocyte
The Specified Disease	Autoimmune uveitis [ICD-11:9A96]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 6.75E-01; Fold-change: -2.61E-02; Z-score: -1.86E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD Disease Classification 11	Circulatory system disease	Click to Show/Hide
ICD-11: BA41	Myocardial infarction	Click to Show/Hide
The Studied Tissue	Peripheral blood
The Specified Disease	Myocardial infarction [ICD-11:BA41-BA50]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.73E-03; Fold-change: 7.35E-01; Z-score: 1.07E+00
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: BA80	Coronary artery disease	Click to Show/Hide
The Studied Tissue	Peripheral blood
The Specified Disease	Coronary artery disease [ICD-11:BA80-BA8Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.81E-01; Fold-change: -8.88E-02; Z-score: -1.15E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: BB70	Aortic valve stenosis	Click to Show/Hide
The Studied Tissue	Calcified aortic valve
The Specified Disease	Aortic stenosis [ICD-11:BB70]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 5.11E-01; Fold-change: -1.37E-01; Z-score: -3.55E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD Disease Classification 12	Respiratory system disease	Click to Show/Hide
ICD-11: 7A40	Central sleep apnoea	Click to Show/Hide
The Studied Tissue	Hyperplastic tonsil
The Specified Disease	Apnea [ICD-11:7A40]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.19E-01; Fold-change: -2.85E-03; Z-score: -1.72E-02
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: CA08	Vasomotor or allergic rhinitis	Click to Show/Hide
The Studied Tissue	Peripheral blood
The Specified Disease	Olive pollen allergy [ICD-11:CA08.00]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 6.85E-01; Fold-change: -1.63E-01; Z-score: -2.11E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: CA0A	Chronic rhinosinusitis	Click to Show/Hide
The Studied Tissue	Sinus mucosa tissue
The Specified Disease	Chronic rhinosinusitis [ICD-11:CA0A]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.28E-01; Fold-change: -5.67E-02; Z-score: -2.90E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: CA22	Chronic obstructive pulmonary disease	Click to Show/Hide
The Studied Tissue	Lung tissue
The Specified Disease	Chronic obstructive pulmonary disease [ICD-11:CA22]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 5.56E-03; Fold-change: 1.38E-01; Z-score: 4.04E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
The Studied Tissue	Small airway epithelium
The Specified Disease	Chronic obstructive pulmonary disease [ICD-11:CA22]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 6.48E-06; Fold-change: 2.92E+00; Z-score: 1.40E+00
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: CA23	Asthma	Click to Show/Hide
The Studied Tissue	Nasal and bronchial airway
The Specified Disease	Asthma [ICD-11:CA23]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.94E-01; Fold-change: 4.89E-02; Z-score: 5.93E-02
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: CB03	Idiopathic interstitial pneumonitis	Click to Show/Hide
The Studied Tissue	Lung tissue
The Specified Disease	Idiopathic pulmonary fibrosis [ICD-11:CB03.4]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.52E-01; Fold-change: -2.19E-01; Z-score: -2.26E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD Disease Classification 13	Digestive system disease	Click to Show/Hide
ICD-11: DA0C	Periodontal disease	Click to Show/Hide
The Studied Tissue	Gingival tissue
The Specified Disease	Periodontal disease [ICD-11:DA0C]
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 2.71E-05; Fold-change: 1.27E-01; Z-score: 5.98E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue adjacent to the diseased tissue of patients
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data of patients in the normal section of the tissue adjacent to the disease section
ICD-11: DA42	Gastritis	Click to Show/Hide
The Studied Tissue	Gastric antrum tissue
The Specified Disease	Eosinophilic gastritis [ICD-11:DA42.2]
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 8.14E-01; Fold-change: 6.17E-02; Z-score: 2.73E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue adjacent to the diseased tissue of patients
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data of patients in the normal section of the tissue adjacent to the disease section
ICD-11: DB92	Non-alcoholic fatty liver disease	Click to Show/Hide
The Studied Tissue	Liver tissue
The Specified Disease	Non-alcoholic fatty liver disease [ICD-11:DB92]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 6.25E-01; Fold-change: -5.57E-01; Z-score: -5.51E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: DB99	Hepatic failure	Click to Show/Hide
The Studied Tissue	Liver tissue
The Specified Disease	Liver failure [ICD-11:DB99.7-DB99.8]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 3.24E-05; Fold-change: -4.16E+00; Z-score: -3.50E+00
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: DD71	Ulcerative colitis	Click to Show/Hide
The Studied Tissue	Colon mucosal tissue
The Specified Disease	Ulcerative colitis [ICD-11:DD71]
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 7.32E-01; Fold-change: -3.62E-02; Z-score: -1.57E-01
DME expression in the diseased tissue of patients DME expression in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of the other disease section
ICD-11: DD91	Irritable bowel syndrome	Click to Show/Hide
The Studied Tissue	Rectal colon tissue
The Specified Disease	Irritable bowel syndrome [ICD-11:DD91.0]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 7.16E-01; Fold-change: 5.65E-02; Z-score: 1.66E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD Disease Classification 14	Skin disease	Click to Show/Hide
ICD-11: EA80	Atopic eczema	Click to Show/Hide
The Studied Tissue	Skin
The Specified Disease	Atopic dermatitis [ICD-11:EA80]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 6.65E-03; Fold-change: 3.22E-01; Z-score: 5.38E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: EA90	Psoriasis	Click to Show/Hide
The Studied Tissue	Skin
The Specified Disease	Psoriasis [ICD-11:EA90]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 7.81E-09; Fold-change: -9.88E-01; Z-score: -6.02E-01
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 2.46E-01; Fold-change: -1.23E-02; Z-score: -8.92E-03
DME expression in the diseased tissue of patients DME expression in the normal tissue adjacent to the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data of patients in the normal section of the tissue adjacent to the disease section Download DME expression data in the tissue of healthy individual
ICD-11: ED63	Acquired hypomelanotic disorder	Click to Show/Hide
The Studied Tissue	Skin
The Specified Disease	Vitiligo [ICD-11:ED63.0]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.32E-01; Fold-change: -5.47E-01; Z-score: -4.60E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: ED70	Alopecia or hair loss	Click to Show/Hide
The Studied Tissue	Skin from scalp
The Specified Disease	Alopecia [ICD-11:ED70]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.44E-02; Fold-change: 3.45E-01; Z-score: 2.95E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: EK0Z	Contact dermatitis	Click to Show/Hide
The Studied Tissue	Skin
The Specified Disease	Sensitive skin [ICD-11:EK0Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 5.77E-01; Fold-change: -2.08E-01; Z-score: -2.56E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD Disease Classification 15	Musculoskeletal system/connective tissue disease	Click to Show/Hide
ICD-11: FA00	Osteoarthritis	Click to Show/Hide
The Studied Tissue	Peripheral blood
The Specified Disease	Arthropathy [ICD-11:FA00-FA5Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 5.24E-01; Fold-change: 6.33E-02; Z-score: 3.33E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
The Studied Tissue	Synovial tissue
The Specified Disease	Osteoarthritis [ICD-11:FA00-FA0Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 3.84E-02; Fold-change: -9.06E-01; Z-score: -8.94E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: FA20	Rheumatoid arthritis	Click to Show/Hide
The Studied Tissue	Peripheral blood
The Specified Disease	Childhood onset rheumatic disease [ICD-11:FA20.Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 6.80E-01; Fold-change: 3.43E-02; Z-score: 1.05E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
The Studied Tissue	Synovial tissue
The Specified Disease	Rheumatoid arthritis [ICD-11:FA20]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 3.71E-02; Fold-change: -9.79E-01; Z-score: -1.13E+00
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: FA24	Juvenile idiopathic arthritis	Click to Show/Hide
The Studied Tissue	Peripheral blood
The Specified Disease	Juvenile idiopathic arthritis [ICD-11:FA24]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.98E-02; Fold-change: 8.63E-02; Z-score: 3.41E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: FA92	Inflammatory spondyloarthritis	Click to Show/Hide
The Studied Tissue	Pheripheral blood
The Specified Disease	Ankylosing spondylitis [ICD-11:FA92.0Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 7.18E-01; Fold-change: 7.18E-03; Z-score: 6.40E-02
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: FB83	Low bone mass disorder	Click to Show/Hide
The Studied Tissue	Bone marrow
The Specified Disease	Osteoporosis [ICD-11:FB83.1]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 7.99E-01; Fold-change: 1.82E-01; Z-score: 2.45E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD Disease Classification 16	Genitourinary system disease	Click to Show/Hide
ICD-11: GA10	Endometriosis	Click to Show/Hide
The Studied Tissue	Endometrium tissue
The Specified Disease	Endometriosis [ICD-11:GA10]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.09E-01; Fold-change: -9.50E-02; Z-score: -2.41E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: GC00	Cystitis	Click to Show/Hide
The Studied Tissue	Bladder tissue
The Specified Disease	Interstitial cystitis [ICD-11:GC00.3]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.25E-02; Fold-change: -2.09E+00; Z-score: -2.00E+00
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD Disease Classification 19	Condition originating in perinatal period	Click to Show/Hide
ICD-11: KA21	Short gestation disorder	Click to Show/Hide
The Studied Tissue	Myometrium
The Specified Disease	Preterm birth [ICD-11:KA21.4Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 3.01E-01; Fold-change: -2.66E-02; Z-score: -1.35E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD Disease Classification 20	Developmental anomaly	Click to Show/Hide
ICD-11: LD2C	Overgrowth syndrome	Click to Show/Hide
The Studied Tissue	Adipose tissue
The Specified Disease	Simpson golabi behmel syndrome [ICD-11:LD2C]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 3.01E-01; Fold-change: -5.79E-02; Z-score: -6.41E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual
ICD-11: LD2D	Phakomatoses/hamartoneoplastic syndrome	Click to Show/Hide
The Studied Tissue	Perituberal tissue
The Specified Disease	Tuberous sclerosis complex [ICD-11:LD2D.2]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.45E-01; Fold-change: 5.81E-02; Z-score: 2.32E-01
DME expression in the diseased tissue of patients DME expression in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Protein Abundances		Click to View the Clearer Original Diagram
Download DME expression barchart for all samples Download DME expression data of patients in the disease section of the tissue Download DME expression data in the tissue of healthy individual

References
1	Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2	Thalidomide metabolism and hydrolysis: mechanisms and implications
3	Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos. 2002 Aug;30(8):869-74.
4	Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
5	Cytochrome P450-mediated metabolism of estrogens and its regulation in human Cancer Lett. 2005 Sep 28;227(2):115-24. doi: 10.1016/j.canlet.2004.10.007.
6	Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A1 enzymes Life Sci. 2010 Aug 14;87(7-8):261-8. doi: 10.1016/j.lfs.2010.07.001.
7	A common CYP1B1 polymorphism is associated with 2-OHE1/16-OHE1 urinary estrone ratio. Clin Chem Lab Med. 2005;43(7):702-6.
8	Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70.
9	Absorption, Distribution, Metabolism, and Excretion of Capmatinib (INC280) in Healthy Male Volunteers and In Vitro Aldehyde Oxidase Phenotyping of the Major Metabolite
10	Increasing the intracellular availability of all-trans retinoic acid in neuroblastoma cells. Br J Cancer. 2005 Feb 28;92(4):696-704.
11	Absorption, Metabolism, and Excretion, In Vitro Pharmacology, and Clinical Pharmacokinetics of Ozanimod, a Novel Sphingosine 1-Phosphate Receptor Modulator
12	Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry. 1999 Oct 26;38(43):14264-70.
13	Role of adrenoceptor-linked signaling pathways in the regulation of CYP1A1 gene expression. Biochem Pharmacol. 2005 Jan 15;69(2):277-87.
14	Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity. Pharmacogenetics. 2000 Aug;10(6):519-30.
15	Participation of CYP2C8 and CYP3A4 in the N-demethylation of imatinib in human hepatic microsomes
16	In vitro biotransformation of imatinib by the tumor expressed CYP1A1 and CYP1B1
17	Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells Chem Res Toxicol. 2003 Mar;16(3):336-49. doi: 10.1021/tx025599q.
18	Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol. 2003 Mar;16(3):336-49.
19	The involvement of CYP3A4 and CYP2C9 in the metabolism of 17 alpha-ethinylestradiol. Drug Metab Dispos. 2004 Nov;32(11):1209-12.
20	Cytochromes P450 1A2 and 3A4 Catalyze the Metabolic Activation of Sunitinib
21	Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids
22	The effect of new lipophilic chelators on the activities of cytosolic reductases and P450 cytochromes involved in the metabolism of anthracycline antibiotics: studies in vitro. Physiol Res. 2004;53(6):683-91.
23	In vitro drug-drug interaction studies with febuxostat, a novel non-purine selective inhibitor of xanthine oxidase: plasma protein binding, identification of metabolic enzymes and cytochrome P450 inhibition Xenobiotica. 2008 May;38(5):496-510. doi: 10.1080/00498250801956350.
24	FDA label of Copanlisib. The 2020 official website of the U.S. Food and Drug Administration.
25	DailyMed : Alitretinoin
26	Metabolism of carvedilol in dogs, rats, and mice Drug Metab Dispos. 1998 Oct;26(10):958-69.
27	Human CYP1B1 and anticancer agent metabolism: mechanism for tumor-specific drug inactivation? J Pharmacol Exp Ther. 2001 Feb;296(2):537-41.
28	In vitro characterization of the metabolism of haloperidol using recombinant cytochrome p450 enzymes and human liver microsomes. Drug Metab Dispos. 2001 Dec;29(12):1638-43.
29	Sulfation of 12-hydroxy-nevirapine by human SULTs and the effects of genetic polymorphisms of SULT1A1 and SULT2A1. Biochem Pharmacol. 2022 Oct;204:115243. doi: 10.1016/j.bcp.2022.115243.
30	Brain accumulation of tivozanib is restricted by ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein) in mice
31	Involvement of cytochrome P450 3A enzyme family in the major metabolic pathways of toremifene in human liver microsomes. Biochem Pharmacol. 1994 May 18;47(10):1883-95.
32	CLINICAL PHARMACOLOGY AND BIOPHARMACEUTICS REVIEW: Umeclidinium Bromide
33	Regulation of cytochrome P450 expression by inhibitors of hydroxymethylglutaryl-coenzyme A reductase in primary cultured rat hepatocytes and in rat liver. Drug Metab Dispos. 1996 Nov;24(11):1197-204.
34	Characterization of Stereoselective Metabolism, Inhibitory Effect on Uric Acid Uptake Transporters, and Pharmacokinetics of Lesinurad Atropisomers Drug Metab Dispos. 2019 Feb;47(2):104-113. doi: 10.1124/dmd.118.080549.
35	Pharmacogenomics in drug-metabolizing enzymes catalyzing anticancer drugs for personalized cancer chemotherapy. Curr Drug Metab. 2007 Aug;8(6):554-62.
36	Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
37	A significant role of human cytochrome P450 2C8 in amiodarone N-deethylation: an approach to predict the contribution with relative activity factor. Drug Metab Dispos. 2000 Nov;28(11):1303-10.
38	CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance. Drug Metab Dispos. 2010 Sep;38(9):1393-6.
39	In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine. Biopharm Drug Dispos. 2011 Oct;32(7):398-407.
40	Novel Pathways of Ponatinib Disposition Catalyzed By CYP1A1 Involving Generation of Potentially Toxic Metabolites J Pharmacol Exp Ther. 2017 Oct;363(1):12-19. doi: 10.1124/jpet.117.243246.
41	Clinical pharmacokinetics and pharmacodynamics of solifenacin. Clin Pharmacokinet. 2009;48(5):281-302.
42	Clinical assessment of drug-drug interactions of tasimelteon, a novel dual melatonin receptor agonist J Clin Pharmacol. 2015 Sep;55(9):1004-11. doi: 10.1002/jcph.507.
43	Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2. J Pharmacol Exp Ther. 1993 Apr;265(1):401-7.
44	Cytochrome P450-mediated metabolism of triclosan attenuates its cytotoxicity in hepatic cells
45	Preferred orientations in the binding of 4'-hydroxyacetanilide (acetaminophen) to cytochrome P450 1A1 and 2B1 isoforms as determined by 13C- and 15N-NMR relaxation studies. J Med Chem. 1994 Mar 18;37(6):860-7.
46	The impact of individual human cytochrome P450 enzymes on oxidative metabolism of anticancer drug lenvatinib
47	In vitro and in vivo evidence for the formation of methyl radical from procarbazine: a spin-trapping study. Carcinogenesis. 1992 May;13(5):799-805.
48	Riociguat (adempas): a novel agent for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. P T. 2014 Nov;39(11):749-58.
49	Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes. Drug Metab Dispos. 1999 Nov;27(11):1260-6.
50	Drug Interactions with Angiotensin Receptor Blockers: Role of Human Cytochromes P450
51	Lithium Intoxication in the Elderly: A Possible Interaction between Azilsartan, Fluvoxamine, and Lithium
52	Oxidative metabolism of flunarizine and cinnarizine by microsomes from B-lymphoblastoid cell lines expressing human cytochrome P450 enzymes. Biol Pharm Bull. 1996 Nov;19(11):1511-4.
53	CYP1A1 is a major enzyme responsible for the metabolism of granisetron in human liver microsomes. Curr Drug Metab. 2005 Oct;6(5):469-80.
54	The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Sci Total Environ. 2007 Aug 1;381(1-3):38-46.
55	Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42. doi: 10.1007/s00228-003-0636-9.
56	Studies on the metabolism and biological activity of the epimers of sulindac
57	In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation. Drug Metab Dispos. 2003 Jun;31(6):748-54.
58	Metabolic activation of dacarbazine by human cytochromes P450: the role of CYP1A1, CYP1A2, and CYP2E1. Clin Cancer Res. 1999 Aug;5(8):2192-7.
59	Cytochromes P450 in crustacea. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Nov;121(1-3):157-72.
60	Metabolism of Meloxicam in human liver involves cytochromes P4502C9 and 3A4. Xenobiotica. 1998 Jan;28(1):1-13.
61	Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. J Med Chem. 2009 Nov 26;52(22):7170-85.
62	Exposure-related effects of atazanavir on the pharmacokinetics of raltegravir in HIV-1-infected patients. Ther Drug Monit. 2010 Dec;32(6):782-6.
63	Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug-Drug Interactions in Children
64	PubChem:Risdiplam
65	Identification of cytochrome P450 enzymes involved in the metabolism of FK228, a potent histone deacetylase inhibitor, in human liver microsomes. Biol Pharm Bull. 2005 Jan;28(1):124-9.
66	Rat hepatic CYP1A1 and CYP1A2 induction by menadione. Toxicol Lett. 2005 Feb 15;155(2):253-8.
67	Disruption of endogenous regulator homeostasis underlies the mechanism of rat CYP1A1 mRNA induction by metyrapone. Biochem J. 1998 Apr 1;331 ( Pt 1):273-81.
68	Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate. J Pharmacol Exp Ther. 2002 Feb;300(2):399-407.
69	Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489-94.
70	Identification of cytochrome P450 enzymes involved in the metabolism of zotepine, an antipsychotic drug, in human liver microsomes. Xenobiotica. 1999 Mar;29(3):217-29.
71	Identification of CYP3A4 as the enzyme involved in the mono-N-dealkylation of disopyramide enantiomers in humans. Drug Metab Dispos. 2000 Aug;28(8):937-44.
72	The metabolism of the piperazine-type phenothiazine neuroleptic perazine by the human cytochrome P-450 isoenzymes. Eur Neuropsychopharmacol. 2004 May;14(3):199-208.
73	Retigabine N-glucuronidation and its potential role in enterohepatic circulation. Drug Metab Dispos. 1999 May;27(5):605-12.
74	Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA. Metabolism. 2007 Jul;56(7):887-94.
75	Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro
76	DrugBank(Pharmacology-Metabolism):Finerenone
77	The metabolic profile of azimilide in man: in vivo and in vitro evaluations. J Pharm Sci. 2005 Sep;94(9):2084-95.
78	Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8.
79	CYP26C1 is a hydroxylase of multiple active retinoids and interacts with cellular retinoic acid binding proteins. Mol Pharmacol. 2018 May;93(5):489-503.
80	Metabolism and Disposition of [(14)C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid Tumors
81	Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet A (PUVA) sensitivity. PLoS One. 2013 Sep 23;8(9):e75494.
82	Xenobiotic metabolizing and antioxidant enzymes in normal and neoplastic human breast tissue. Eur J Drug Metab Pharmacokinet. 1998 Oct-Dec;23(4):497-500.
83	Methods to Assess Pulmonary Metabolism.
84	CYP3A but not P-gp plays a relevant role in the in vivo intestinal and hepatic clearance of the delta-specific phosphoinositide-3 kinase inhibitor leniolisib
85	Pharmacokinetics, metabolism, and excretion of licogliflozin, a dual inhibitor of SGLT1/2, in rats, dogs, and humans
86	4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine. J Pharmacol Exp Ther. 2002 Jun;301(3):1025-32.
87	Metabolic pathways of the camptothecin analog AR-67
88	Pharmacokinetics, tissue distribution and identification of putative metabolites of JI-101 - a novel triple kinase inhibitor in rats
89	Beta-adrenergic receptor modulation of the LPS-mediated depression in CYP1A activity in astrocytes. Biochem Pharmacol. 2005 Mar 1;69(5):741-50.
90	Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-trans-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid
91	Cytochrome P450 3A-mediated metabolism of the topoisomerase I inhibitor 9-aminocamptothecin: impact on cancer therapy. Int J Oncol. 2014 Aug;45(2):877-86.
92	Role of 2-methoxyestradiol, an Endogenous Estrogen Metabolite, in Health and Disease. Mini Rev Med Chem. 2015;15(5):427-38.
93	Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients. Br J Pharmacol. 2013 Apr;168(7):1687-706.
94	Metabolic map and bioactivation of the anti-tumour drug noscapine
95	Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous ipriflavone in rats. J Pharm Pharmacol. 2006 Apr;58(4):449-57.
96	Investigating the Contribution of Drug-Metabolizing Enzymes in Drug-Drug Interactions of Dapivirine and Miconazole
97	Comparative Metabolism of Batracylin (NSC 320846) and N-acetylbatracylin (NSC 611001) Using Human, Dog, and Rat Preparations In Vitro
98	Steady-state pharmacokinetics of a new antipsychotic agent perospirone and its active metabolite, and its relationship with prolactin response. Ther Drug Monit. 2004 Aug;26(4):361-5.
99	The wide variability of perospirone metabolism and the effect of perospirone on prolactin in psychiatric patients
100	In vitro and in vivo clinical pharmacology of dimethyl benzoylphenylurea, a novel oral tubulin-interactive agent
101	Phase I study of continuous weekly dosing of dimethylamino benzoylphenylurea (BPU) in patients with solid tumours
102	Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen. Eur J Pharm Biopharm. 2009 Jun;72(2):471-7.
103	In vitro metabolism of the novel, highly selective oral angiogenesis inhibitor motesanib diphosphate in preclinical species and in humans
104	An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant
105	Glucuronidation of the nonsteroidal antiestrogen EM-652 (SCH 57068), by human and monkey steroid conjugating UDP-glucuronosyltransferase enzymes
106	Identification of cytochrome P450 isoform involved in the metabolism of YM992, a novel selective serotonin re-uptake inhibitor, in human liver microsomes
107	Pharmacokinetics and metabolism of TR-14035, a novel antagonist of a4ss1/a4ss7 integrin mediated cell adhesion, in rat and dog
108	In vitro evaluation of potential in vivo probes for human flavin-containing monooxygenase (FMO): metabolism of benzydamine and caffeine by FMO and P450 isoforms. Br J Clin Pharmacol. 2000 Oct;50(4):311-4.
109	Effects of cytokine-induced macrophages on the response of tumor cells to banoxantrone (AQ4N)
110	Bioreductively activated antitumor N-oxides: the case of AQ4N, a unique approach to hypoxia-activated cancer chemotherapy
111	CYP2S1 is negatively regulated by corticosteroids in human cell lines. Toxicol Lett. 2012 Feb 25;209(1):30-4.
112	Identification of the cytochromes P450 that catalyze coumarin 3,4-epoxidation and 3-hydroxylation
113	Carcinogenic 3-nitrobenzanthrone but not 2-nitrobenzanthrone is metabolised to an unusual mercapturic acid in rats
114	Sudan I is a potential carcinogen for humans: evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes
115	Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2. Mol Pharmacol. 2002 Jul;62(1):143-53.
116	Metabolism of equilenin in MCF-7 and MDA-MB-231 human breast cancer cells
117	Role of cytochrome P450 isoenzymes in metabolism of O(6)-benzylguanine: implications for dacarbazine activation. Clin Cancer Res. 2001 Dec;7(12):4239-44.
118	Simultaneous determination of blonanserin and its metabolite in human plasma and urine by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study
119	Blonanserin: a review of its use in the management of schizophrenia
120	Simultaneous determination of blonanserin and its four metabolites in human plasma using ultra-performance liquid chromatography-tandem mass spectrometry
121	Determination of the cardiac drug amiodarone and its N-desethyl metabolite in sludge samples
122	Amiodarone and concurrent antiretroviral therapy: a case report and review of the literature
123	The metabolism of amiodarone by various CYP isoenzymes of human and rat, and the inhibitory influence of ketoconazole. J Pharm Pharm Sci. 2008;11(1):147-59.
124	Role of CYP3A in bromperidol metabolism in rat in vitro and in vivo Xenobiotica. 1999 Aug;29(8):839-46. doi: 10.1080/004982599238281.
125	Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicumarol, and testosterone oxidation
126	Coumarin metabolism by rat esophageal microsomes and cytochrome P450 2A3
127	Assessment of the pulmonary CYP1A1 metabolism of mavoglurant (AFQ056) in rat
128	Pharmacokinetics of dacarbazine (DTIC) in pregnancy
129	In vitro characterization and pharmacokinetics of dapagliflozin (BMS-512148), a potent sodium-glucose cotransporter type II inhibitor, in animals and humans Drug Metab Dispos. 2010 Mar;38(3):405-14. doi: 10.1124/dmd.109.029165.
130	Pharmacokinetics and metabolism of delamanid, a novel anti-tuberculosis drug, in animals and humans: importance of albumin metabolism in vivo. Drug Metab Dispos. 2015 Aug;43(8):1267-76.
131	Metabolism, excretion, and mass balance of the HIV-1 integrase inhibitor dolutegravir in humans
132	DrugBank(Pharmacology-Metabolism)Estradiol acetate
133	Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett. 2005 Sep 28;227(2):115-24.
134	Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706.
135	The metabolism of estradiol; oral compared to intravenous administration J Steroid Biochem. 1985 Dec;23(6A):1065-70. doi: 10.1016/0022-4731(85)90068-8.
136	Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
137	In vitro drug-drug interaction studies with febuxostat, a novel non-purine selective inhibitor of xanthine oxidase: plasma protein binding, identification of metabolic enzymes and cytochrome P450 inhibition. Xenobiotica. 2008 May;38(5):496-510.
138	Roles of different CYP enzymes in the formation of specific fluvastatin metabolites by human liver microsomes. Basic Clin Pharmacol Toxicol. 2009 Nov;105(5):327-32.
139	Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
140	Characterisation of the cytochrome P450 enzymes involved in the in vitro metabolism of granisetron. Br J Clin Pharmacol. 1994 Dec;38(6):557-66.
141	Roles of human CYP2A6 and 2B6 and rat CYP2C11 and 2B1 in the 10-hydroxylation of (-)-verbenone by liver microsomes. Drug Metab Dispos. 2003 Aug;31(8):1049-53.
142	Advances in high-resolution MS and hepatocyte models solve a long-standing metabolism challenge: the loratadine story. Bioanalysis. 2016 Aug;8(16):1645-62.
143	Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. Drug Metab Dispos. 2012 Apr;40(4):761-71.
144	In vitro metabolism of perospirone in rat, monkey and human liver microsomes
145	A prospective longitudinal study of growth in twin gestations compared with growth in singleton pregnancies. I. The fetal head J Ultrasound Med. 1991 Aug;10(8):439-43. doi: 10.7863/jum.1991.10.8.439.
146	Population pharmacokinetic modeling of motesanib and its active metabolite, M4, in cancer patients
147	Inhibitory effects of nicardipine to cytochrome P450 (CYP) in human liver microsomes. Biol Pharm Bull. 2005 May;28(5):882-5.
148	Metabolic pro?ling of tyrosine kinase inhibitor nintedanib using metabolomics J Pharm Biomed Anal. 2020 Feb 20;180:113045. doi: 10.1016/j.jpba.2019.113045.
149	Activation of 3-nitrobenzanthrone and its metabolites by human acetyltransferases, sulfotransferases and cytochrome P450 expressed in Chinese hamster V79 cells
150	Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42.
151	Value of preemptive CYP2C19 genotyping in allogeneic stem cell transplant patients considered for pentamidine administration. Clin Transplant. 2011 May-Jun;25(3):E271-5.
152	DrugBank(Pharmacology-Metabolism)Phenacetin
153	Tumour cytochrome P450 and drug activation. Curr Pharm Des. 2002;8(15):1335-47.
154	Plasma kinetics of procarbazine and azo-procarbazine in humans Anticancer Drugs. 2006 Jan;17(1):75-80. doi: 10.1097/01.cad.0000181591.85476.aa.
155	Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2 Inhibitor PT2385 In Vivo and In Vitro
156	Population pharmacokinetics of riociguat and its metabolite in patients with chronic thromboembolic pulmonary hypertension from routine clinical practice
157	Clinical Pharmacokinetic and Pharmacodynamic Profile of Riociguat
158	Pharmacokinetics, distribution, and metabolism of [14C]sunitinib in rats, monkeys, and humans
159	Endoxifen and other metabolites of tamoxifen inhibit human hydroxysteroid sulfotransferase 2A1 (hSULT2A1). Drug Metab Dispos. 2014 Nov;42(11):1843-50.
160	Metabolism and transport of tamoxifen in relation to its effectiveness: new perspectives on an ongoing controversy. Future Oncol. 2014 Jan;10(1):107-22.
161	Identification and biological activity of tamoxifen metabolites in human serum Biochem Pharmacol. 1983 Jul 1;32(13):2045-52. doi: 10.1016/0006-2952(83)90425-2.
162	PharmGKB summary: tamoxifen pathway, pharmacokinetics Pharmacogenet Genomics. 2013 Nov;23(11):643-7. doi: 10.1097/FPC.0b013e3283656bc1.
163	Clinical assessment of drug-drug interactions of tasimelteon, a novel dual melatonin receptor agonist. J Clin Pharmacol. 2015 Sep;55(9):1004-11.
164	Retinoic acid metabolism and mechanism of action: a review
165	Total determination of triclabendazole and its metabolites in bovine tissues using liquid chromatography-tandem mass spectrometry J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Mar 1;1109:54-59. doi: 10.1016/j.jchromb.2019.01.021.
166	Egaten FDA label
167	Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like and antidepressant-like actions through its potent inhibition of norepinephrine reuptake

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