| General Information of Drug Metabolite (DM) (ID: DM003002) |
| DM Name |
Promethazine Hydroxy metabolite
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 2D6 (CYP2D6)
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DME0009
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| Oxidation - Hydroxylation |
Promethazine
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[1] , [2] , [3] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Promethazine |
DR1353
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Approved |
Functional nausea/vomiting |
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| References |
| 1 |
An HPLC-ESI-MS method for simultaneous determination of fourteen metabolites of promethazine and caffeine and its application to pharmacokinetic study of the combination therapy against motion sickness J Pharm Biomed Anal. 2012 Mar 25;62:119-28. doi: 10.1016/j.jpba.2011.12.033.
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| 2 |
A liquid chromatographic method for the simultaneous determination of promethazine and three of its metabolites in plasma using electrochemical and UV detectors J Chromatogr Sci. 2001 Feb;39(2):70-2. doi: 10.1093/chromsci/39.2.70.
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| 3 |
CYP2D6 is the principal cytochrome P450 responsible for metabolism of the histamine H1 antagonist promethazine in human liver microsomes. Pharmacogenetics. 1996 Oct;6(5):449-57.
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