Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM003033)
DM Name	O-desalkylquetiapine

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 3A4 (CYP3A4)	DME0001	Quetiapine fumarate	Oxidation - N-Dealkylation	Quetiapine fumarate	[1]
Cytochrome P450 3A5 (CYP3A5)	DME0012	Quetiapine fumarate	Oxidation - N-Dealkylation	Quetiapine fumarate	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Quetiapine fumarate		DR1376	Approved		Schizophrenia

References
1	Metabolism of quetiapine by CYP3A4 and CYP3A5 in presence or absence of cytochrome B5. Drug Metab Dispos. 2009 Feb;37(2):254-8.

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