General Information of Drug Metabolite (DM) (ID: DM003606)
DM Name
SQ-109 Metabolite M4-2
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 2D6 (CYP2D6) DME0009 Multi-steps Reaction - Ring oxidation; Epoxidation; rearrangement SQ-109 [1]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Multi-steps Reaction - Ring oxidation; Epoxidation; rearrangement SQ-109 [1]
Full List of Drug(s) That Produce This DM By Metabolism
SQ-109 DR1852 Phase 2 Pulmonary tuberculosis
References
1 Interspecies pharmacokinetics and in vitro metabolism of SQ109. Br J Pharmacol. 2006 Mar;147(5):476-85.

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