Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM003630)
DM Name
UK-453,061 Metabolite M17
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 3A4 (CYP3A4) DME0001
UK-453,061
Oxidation - Mono-oxidation UK-453,061 [1]
Full List of Drug(s) That Produce This DM By Metabolism
UK-453,061 DR1825 Phase 2 Human immunodeficiency virus infection
References
1 Excretion and metabolism of lersivirine (5-{[3,5-diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a next-generation non-nucleoside reverse transcriptase inhibitor, after administration of [14C]Lersivirine to healthy volunteers. Drug Metab Dispos. 2010 May;38(5):789-800.

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