Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM004861)
DM Name	Retigabine-N4-glucuronide
Structure
Structure	3D MOL is unavailable			2D MOL is unavailable

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
UDP-glucuronosyltransferase 1A3 (UGT1A3)	DME0041	Retigabine	Conjugation - Glucuronidation	Retigabine	[1] , [2] , [3]
UDP-glucuronosyltransferase 1A4 (UGT1A4)	DME0048	Retigabine	Conjugation - Glucuronidation	Retigabine	[1] , [2] , [3]
UDP-glucuronosyltransferase 1A9 (UGT1A9)	DME0042	Retigabine	Conjugation - Glucuronidation	Retigabine	[1] , [2] , [3]

Full List of Drug(s) That Produce This DM By Metabolism
Retigabine		DR1407	Phase 4		Epilepsy

References
1	Retigabine: the newer potential antiepileptic drug
2	Retigabine N-glucuronidation and its potential role in enterohepatic circulation. Drug Metab Dispos. 1999 May;27(5):605-12.
3	N-Glucuronidation of the antiepileptic drug retigabine: results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler-Najjar type II. Metabolism. 2006 Jun;55(6):711-21.

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