Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM005166)
DM Name	Remdesivir M1
Structure
Structure	3D MOL is unavailable			2D MOL is unavailable

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 2C8 (CYP2C8)	DME0018	Remdesivir	Unclear - Unclear	Remdesivir	[1]
Cytochrome P450 2D6 (CYP2D6)	DME0009	Remdesivir	Unclear - Unclear	Remdesivir	[1]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Remdesivir	Unclear - Unclear	Remdesivir	[1]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Carboxylesterase 1 (CES1)	DME0054	Remdesivir Nucleoside Monophosphate	Unclear - Unclear	Remdesivir	[1]
Cathepsin A (CTSA)	DME0071	Remdesivir Nucleoside Monophosphate	Unclear - Unclear	Remdesivir	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Remdesivir		DR5430	Approved		Coronavirus Disease 2019 (COVID-19)

References
1	Viral target and metabolism-based rationale for combined use of recently authorized small molecule COVID-19 medicines: Molnupiravir, nirmatrelvir, and remdesivir

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