Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM005427)
DM Name
Doxapram metabolite D
Structure
3D MOL is unavailable 2D MOL is unavailable
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
Cytochrome P450 3A4 (CYP3A4) DME0001
Doxapram metabolite C
Oxidation - Deethylation Doxapram hydrochloride [1] , [2] , [3]
Cytochrome P450 3A5 (CYP3A5) DME0012
Doxapram metabolite C
Oxidation - Deethylation Doxapram hydrochloride [1] , [2] , [3]
Full List of Drug(s) That Produce This DM By Metabolism
Doxapram hydrochloride DR0541 Approved Chronic obstructive pulmonary disease
References
1 Doxapram metabolism in human fetal hepatic organ culture
2 Identification of doxapram metabolites using high pressure ion exchange chromatography and mass spectroscopy
3 Population pharmacokinetics of doxapram in low-birth-weight Japanese infants with apnea. Eur J Pediatr. 2015 Apr;174(4):509-18.

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