Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM005789)
DM Name	3beta-sulfated-tibolone

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Sulfotransferase 1E1 (SULT1E1)	DME0061	3beta-OH-tibolone	Conjugation - Sulfation	Tibolone	[1] , [2] , [3]
Sulfotransferase 2A1 (SULT2A1)	DME0074	3beta-OH-tibolone	Conjugation - Sulfation	Tibolone	[1] , [2] , [3]
Sulfotransferase 2B1 (SULT2B1)	DME0384	3beta-OH-tibolone	Conjugation - Sulfation	Tibolone	[1] , [2] , [3]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Sulfotransferase 1E1 (SULT1E1)	DME0061	3alpha-17beta-disulfated-tibolone	Conjugation - Sulfation	Tibolone	[1] , [2] , [3]
Sulfotransferase 2A1 (SULT2A1)	DME0074	3alpha-17beta-disulfated-tibolone	Conjugation - Sulfation	Tibolone	[1] , [2] , [3]
Sulfotransferase 2B1 (SULT2B1)	DME0384	3alpha-17beta-disulfated-tibolone	Conjugation - Sulfation	Tibolone	[1] , [2] , [3]

Full List of Drug(s) That Produce This DM By Metabolism
Tibolone		DR1590	Phase 4		Depression

References
1	Sulfation of tibolone and tibolone metabolites by expressed human cytosolic sulfotransferases. J Steroid Biochem Mol Biol. 2004 Apr;88(4-5):383-91.
2	Sulfation of tibolone metabolites by human postmenopausal liver and small intestinal sulfotransferases (SULTs). Steroids. 2006 May;71(5):343-51.
3	Antioxidant effect of the active metabolites of tibolone

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