General Information of Drug Metabolite (DM) (ID: DM005791)
DM Name
3alpha-17beta-disulfated-tibolone
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Sulfotransferase 1E1 (SULT1E1) DME0061 Conjugation - Sulfation Tibolone [1] , [2] , [3]
Sulfotransferase 2A1 (SULT2A1) DME0074 Conjugation - Sulfation Tibolone [1] , [2] , [3]
Sulfotransferase 2B1 (SULT2B1) DME0384 Conjugation - Sulfation Tibolone [1] , [2] , [3]
Full List of Drug(s) That Produce This DM By Metabolism
Tibolone DR1590 Phase 4 Depression
References
1 Sulfation of tibolone and tibolone metabolites by expressed human cytosolic sulfotransferases. J Steroid Biochem Mol Biol. 2004 Apr;88(4-5):383-91.
2 Sulfation of tibolone metabolites by human postmenopausal liver and small intestinal sulfotransferases (SULTs). Steroids. 2006 May;71(5):343-51.
3 Antioxidant effect of the active metabolites of tibolone

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