| General Information of Drug Metabolite (DM) (ID: DM005821) |
| DM Name |
5-hydroxy tropisetron
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 2D6 (CYP2D6)
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DME0009
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| Oxidation - Hydrolyzationn |
Tropisetron
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[1] , [2] , [3] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Tropisetron |
DR1653
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Phase 4 |
Anaesthesia |
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| References |
| 1 |
Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of dolasetron. Comparison with other indole-containing 5-HT3 antagonists. Drug Metab Dispos. 1996 May;24(5):602-9.
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| 2 |
The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron. Drug Metab Dispos. 1994 Mar-Apr;22(2):269-74.
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| 3 |
Pharmacokinetics and metabolism of the 5-hydroxytryptamine antagonist tropisetron after single oral doses in humans
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