| General Information of Drug Metabolite (DM) (ID: DM006011) |
| DM Name |
TAK-875 Metabolite M-I
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Unclear - Unclear |
TAK-875
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[1] |
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Cytochrome P450 3A5 (CYP3A5)
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DME0012
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| Unclear - Unclear |
TAK-875
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[1] |
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| DME(s) Metabolizing This DM |
| DME Name |
DME ID |
Product |
Reaction |
Related Drug |
REF |
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UDP-glucuronosyltransferase 1A3 (UGT1A3)
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DME0041
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| Conjugation - Conjugation |
TAK-875
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| TAK-875 |
DR1882
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Phase 3 |
Diabetes mellitus |
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| References |
| 1 |
Disposition and metabolism of the G protein-coupled receptor 40 agonist TAK-875 (fasiglifam) in rats, dogs, and humans. Xenobiotica. 2019 Apr;49(4):433-445.
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