Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM006168)
DM Name	Hydroxilated form of dolutegravir (M3)

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 3A4 (CYP3A4)	DME0001	Dolutegravir sodium	Oxidation - Hydrolyzationn	Dolutegravir sodium	[1]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Cytochrome P450 1A1 (CYP1A1)	DME0006	2,4- difluorobenzaldehyde (M5 dolutegravir)	Hydrolysis - Hydrolysis	Dolutegravir sodium	[1]
Cytochrome P450 1A1 (CYP1A1)	DME0006	Hydrolized form of dolutegravir (M1)	Hydrolysis - Hydrolysis	Dolutegravir sodium	[1]
Cytochrome P450 1B1 (CYP1B1)	DME0023	2,4- difluorobenzaldehyde (M5 dolutegravir)	Hydrolysis - Hydrolysis	Dolutegravir sodium	[1]
Cytochrome P450 1B1 (CYP1B1)	DME0023	Hydrolized form of dolutegravir (M1)	Hydrolysis - Hydrolysis	Dolutegravir sodium	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Dolutegravir sodium		DR0526	Approved		Human immunodeficiency virus infection

References
1	Metabolism, excretion, and mass balance of the HIV-1 integrase inhibitor dolutegravir in humans

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