| General Information of Drug Metabolite (DM) (ID: DM006353) |
| DM Name |
Sitagliptin M2 and M5 Metabolites
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 2C8 (CYP2C8)
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DME0018
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| Other reaction - Cyclization |
Sitagliptin
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[1] |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Other reaction - Cyclization |
Sitagliptin
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Sitagliptin |
DR1490
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Approved |
Diabetes mellitus |
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| References |
| 1 |
Metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C]sitagliptin in humans
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