Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM006438)
DM Name	1-cortienic acid (PJ-90)
PubChem CID	175268755

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Serum paraoxonase/arylesterase 1 (PON1)	DME0169	1-cortienic acid etabonate (PJ-91)	Hydrolysis - Hydrolysis	Loteprednol etabonate	[1]
Serum paraoxonase/arylesterase 1 (PON1)	DME0169	HydroxylLoteprednol	Hydrolysis - Hydrolysis	Loteprednol etabonate	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Loteprednol etabonate		DR0985	Approved		Conjunctivitis

References
1	Identification of esterase involved in the metabolism of two corticosteroid soft drugs. Biochem Pharmacol. 2017 Mar 1;127:82-89.

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