Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM006672)
DM Name	5-hydroxymethyl-flucloxacillin
Structure
Structure	3D MOL is unavailable			2D MOL is unavailable

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 2C9 (CYP2C9)	DME0019	Flucloxacillin	Oxidation - Oxidationn	Flucloxacillin	[1]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Flucloxacillin	Oxidation - Oxidationn	Flucloxacillin	[1]
Cytochrome P450 3A7 (CYP3A7)	DME0015	Flucloxacillin	Oxidation - Oxidationn	Flucloxacillin	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Flucloxacillin		DR0703	Phase 4		Staphylococcus infection

References
1	Characterization of kinetics of human cytochrome P450s involved in bioactivation of flucloxacillin: inhibition of CYP3A-catalysed hydroxylation by sulfaphenazole. Br J Pharmacol. 2019 Feb;176(3):466-477.

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