General Information of Drug Metabolite (DM) (ID: DM006729)
DM Name
ARQ-501 M4-1
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Quinone reductase 1 (NQO1) DME0097 Multi-steps Reaction - Reduction; glucuronidation ARQ-501 [1]
Full List of Drug(s) That Produce This DM By Metabolism
ARQ-501 DR1869 Phase 2 Leiomyosarcoma
References
1 Metabolic profile, enzyme kinetics, and reaction phenotyping of -lapachone metabolism in human liver and intestine in vitro

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