| General Information of Drug Metabolite (DM) (ID: DM017291) |
| DM Name |
S-Oxide
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 2A6 (CYP2A6)
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DME0005
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| Unclear - Unclear |
SM-10661
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[1] , [2] , [3] |
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Dimethylaniline oxidase 1 (FMO1)
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DME0059
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| Unclear - Unclear |
SM-10661
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[1] , [2] , [3] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| SM-10661 |
DR3042
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Discontinued in Phase 2 |
Sepsis |
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| References |
| 1 |
(+)-cis-3,5-dimethyl-2-(3-pyridyl) thiazolidin-4-one hydrochloride (SM-12502) as a novel substrate for cytochrome P450 2A6 in human liver microsomes
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| 2 |
S-oxidation of (+)-cis-3,5-dimethyl-2-(3-pyridyl)-thiazolidin-4-one hydrochloride by rat hepatic flavin-containing monooxygenase 1 expressed in yeast
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| 3 |
A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502)
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