General Information of Drug Metabolite (DM) (ID: DM017607)
DM Name
Sotorasib Metabolite M30
Structure
3D MOL is unavailable 2D MOL is unavailable
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytosol aminopeptidase (LAP3) DME0569 Hydrolysis - Hydrolysis Sotorasib [1] , [2]
Gamma-glutamyltranspeptidase 5 (GGT5) DME0432 Hydrolysis - Hydrolysis Sotorasib [1] , [2]
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
Bleomycin hydrolase (BLMH) DME0086 Hydrolysis - Hydrolysis Sotorasib [1]
Full List of Drug(s) That Produce This DM By Metabolism
Sotorasib DR3515 Phase 3 Lung cancer
References
1 Absorption, Distribution, Metabolism, and Excretion of [(14)C]-Sotorasib in Rats and Dogs: Interspecies Differences in Absorption, Protein Conjugation and Metabolism
2 Absorption, metabolism and excretion of [(14)C]-sotorasib in healthy male subjects: characterization of metabolites and a minor albumin-sotorasib conjugate

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