Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM017910)
DM Name	Rilpivirine M1

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 3A4 (CYP3A4)	DME0001	Rilpivirine hydrochloride	Oxidation - Hydroxylation	Rilpivirine hydrochloride	[1]
Cytochrome P450 3A5 (CYP3A5)	DME0012	Rilpivirine hydrochloride	Oxidation - Hydroxylation	Rilpivirine hydrochloride	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Rilpivirine hydrochloride		DR1424	Approved		Human immunodeficiency virus infection

References
1	Human biotransformation of the nonnucleoside reverse transcriptase inhibitor rilpivirine and a cross-species metabolism comparison. Antimicrob Agents Chemother. 2013 Oct;57(10):5067-79.

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