| General Information of Drug Metabolite (DM) (ID: DM017918) |
| DM Name |
5-OH-rofecoxib O-glucuronide
|
|
|
|
|
|
|
|
| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
|
UDP-glucuronosyltransferase 2B15 (UGT2B15)
|
DME0049
|
| Conjugation - Glucuronidation |
Rofecoxib
|
[1] , [2] |
|
UDP-glucuronosyltransferase 2B7 (UGT2B7)
|
DME0040
|
| Conjugation - Glucuronidation |
Rofecoxib
|
[1] , [2] |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Full List of Drug(s) That Produce This DM By Metabolism |
| Rofecoxib |
DR1433
|
Approved |
Rheumatoid arthritis |
|
|
| References |
| 1 |
Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
|
| 2 |
Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism
|
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.
