General Information of Drug Metabolite (DM) (ID: DM017940)
DM Name
TAK-438 N-sulfate
Structure
3D MOL is unavailable 2D MOL is unavailable
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Sulfotransferase 2A1 (SULT2A1) DME0074 Oxidation - Sulfonation Vonoprazan [1] , [2]
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
Cytochrome P450 2C9 (CYP2C9) DME0019 Oxidation - Hydroxylation Vonoprazan [1] , [2]
Full List of Drug(s) That Produce This DM By Metabolism
Vonoprazan DR1705 Phase 4 Gastro-oesophageal reflux disease
References
1 Vonoprazan fumarate, a novel potassium-competitive acid blocker, in the management of gastroesophageal reflux disease: safety and clinical evidence to date
2 In vitro metabolism of TAK-438, vonoprazan fumarate, a novel potassium-competitive acid blocker. Xenobiotica. 2017 Dec;47(12):1027-1034.

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