Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM018040)
DM Name	(E)-10-hydroxynortriptyline

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 2D6 (CYP2D6)	DME0009	(E)-10-hydroxyamitriptyline	Unclear - Unclear	Amitriptyline hydrochloride	[1] , [2]

Full List of Drug(s) That Produce This DM By Metabolism
Amitriptyline hydrochloride		DR0095	Approved		Depression

References
1	CYP2D6 and CYP2C19 genotypes and amitriptyline metabolite ratios in a series of medicolegal autopsies
2	Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype

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