Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM018295)
DM Name	IC200565

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 3A4 (CYP3A4)	DME0001	Lumateperone tosylate	Oxidation - N-desmethylation	lumateperone tosylate	[1]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Lumateperone tosylate	Oxidation - Dealkylation	lumateperone tosylate	[2]
Cytochrome P450 3A4 (CYP3A4)	DME0001	ITI-007	Oxidation - Dealkylation	ITI-007	[1]

Full List of Drug(s) That Produce This DM By Metabolism
lumateperone tosylate		DR5480	Approved		Schizophrenia

ITI-007		DR3407	Phase 3		Schizophrenia

References
1	An evaluation of lumateperone tosylate for the treatment of schizophrenia
2	Dopamine D(2) receptor occupancy of lumateperone (ITI-007): a Positron Emission Tomography Study in patients with schizophrenia

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