| General Information of Drug Metabolite (DM) (ID: DM019861) |
| DM Name |
LMP400 Metabolite M2
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 (CYP)
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DMEN060
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| Oxidation - O-dealkylation |
LMP400
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| LMP400 |
DR3115
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Phase 1 |
Lymphoma |
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| References |
| 1 |
Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I poisons
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