Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM019996)
DM Name	Alectinib metabolite M5

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 3A4 (CYP3A4)	DME0001	Alectinib hydrochloride	Oxidation - Hydroxylation	Alectinib hydrochloride	[1]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Aldehyde dehydrogenase 1 (ALDH1)	DME0286	Alectinib metabolite M1b	Oxidation - Oxidation	Alectinib hydrochloride	[1]
Aldehyde dehydrogenase 1 (ALDH1)	DME0286	Alectinib metabolite M1a	Oxidation - Oxidation	Alectinib hydrochloride	[1]
Aldehyde dehydrogenase 2 (ALDH2)	DME0077	Alectinib metabolite M1b	Oxidation - Oxidation	Alectinib hydrochloride	[1]
Aldehyde dehydrogenase 2 (ALDH2)	DME0077	Alectinib metabolite M1a	Oxidation - Oxidation	Alectinib hydrochloride	[1]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Alectinib metabolite M4	Oxidation - Oxidation	Alectinib hydrochloride	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Alectinib hydrochloride		DR0059	Approved		Lung cancer

References
1	In vitro metabolism of alectinib, a novel potent ALK inhibitor, in human: contribution of CYP3A enzymes. Xenobiotica. 2018 Jun;48(6):546-554.

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