| General Information of Drug Metabolite (DM) (ID: DM000245) |
| DM Name |
Letrozole ketone analog metabolite
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 2A6 (CYP2A6)
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DME0005
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| Unclear - Unclear |
Letrozole
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[1] |
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| DME(s) Metabolizing This DM |
| DME Name |
DME ID |
Product |
Reaction |
Related Drug |
REF |
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Cytochrome P450 2A6 (CYP2A6)
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DME0005
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| Unclear - Unclear |
Letrozole
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[1] |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Unclear - Unclear |
Letrozole
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Letrozole |
DR0929
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Approved |
Breast cancer |
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| References |
| 1 |
Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4'-methanol-bisbenzonitrile in vitro. Cancer Chemother Pharmacol. 2009 Oct;64(5):867-75.
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