| General Information of Drug Metabolite (DM) (ID: DM000780) |
| DM Name |
Desloratadine N-glucuronidation
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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UDP-glucuronosyltransferase 2B10 (UGT2B10)
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DME0205
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| Conjugation - Glucuronidation |
Desloratadine
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[1] , [2] |
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| DME(s) Metabolizing This DM |
| DME Name |
DME ID |
Product |
Reaction |
Related Drug |
REF |
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Cytochrome P450 2C8 (CYP2C8)
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DME0018
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| Oxidation - Hydroxylation |
Desloratadine
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[1] , [2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Desloratadine |
DR1761
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Approved |
Allergic rhinitis |
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| References |
| 1 |
Further characterization of the metabolism of desloratadine and its cytochrome P450 and UDP-glucuronosyltransferase inhibition potential: identification of desloratadine as a relatively selective UGT2B10 inhibitor. Drug Metab Dispos. 2015 Sep;43(9):1294-302.
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| 2 |
A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement Drug Metab Dispos. 2015 Apr;43(4):523-33. doi: 10.1124/dmd.114.062620.
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