Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM000819)
DM Name	Dexrazoxane metabolite B
Structure
Structure	3D MOL is unavailable			2D MOL is unavailable

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Dihydropyrimidinase (DPYS)	DMEN004	Dexrazoxane hydrochloride	Hydrolysis - Hydrolysis	Dexrazoxane hydrochloride	[1] , [2]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Dihydroorotase (pyrC)	DME1829	ADR-925	Hydrolysis - Hydrolysis	Dexrazoxane hydrochloride	[1] , [2]

Full List of Drug(s) That Produce This DM By Metabolism
Dexrazoxane hydrochloride		DR1772	Approved		Breast cancer

References
1	Metabolism of the cardioprotective drug dexrazoxane and one of its metabolites by isolated rat myocytes, hepatocytes, and blood. Drug Metab Dispos. 2005 Jun;33(6):719-25.
2	Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation. Circ Heart Fail. 2021 Nov;14(11):e008209. doi: 10.1161/CIRCHEARTFAILURE.120.008209.

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