Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM000821)
DM Name
Dexrazoxane metabolite C
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Dihydropyrimidinase (DPYS) DMEN004
Dexrazoxane hydrochloride
Hydrolysis - Hydrolysis Dexrazoxane hydrochloride [1] , [2]
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
Dihydroorotase (pyrC) DME1829
ADR-925
Hydrolysis - Hydrolysis Dexrazoxane hydrochloride [1] , [2]
Full List of Drug(s) That Produce This DM By Metabolism
Dexrazoxane hydrochloride DR1772 Approved Breast cancer
References
1 Metabolism of the cardioprotective drug dexrazoxane and one of its metabolites by isolated rat myocytes, hepatocytes, and blood. Drug Metab Dispos. 2005 Jun;33(6):719-25.
2 Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation. Circ Heart Fail. 2021 Nov;14(11):e008209. doi: 10.1161/CIRCHEARTFAILURE.120.008209.

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