Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM001971)
DM Name
DM-6705
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Albumin (ALB) DMEN043
Delamanid
Unclear - Unclear Delamanid [1] , [2] , [3] , [4]
Full List of Drug(s) That Produce This DM By Metabolism
Delamanid DR0432 Approved Pulmonary tuberculosis
References
1 Pharmacokinetics and metabolism of delamanid, a novel anti-tuberculosis drug, in animals and humans: importance of albumin metabolism in vivo. Drug Metab Dispos. 2015 Aug;43(8):1267-76.
2 Liquid chromatography-tandem mass spectrometry analysis of delamanid and its metabolite in human cerebrospinal fluid using protein precipitation and on-line solid-phase extraction. J Pharm Biomed Anal. 2023 Apr 1;227:115281. doi: 10.1016/j.jpba.2023.115281.
3 Relative bioavailability of delamanid 50?mg tablets dispersed in water in healthy adult volunteers. Br J Clin Pharmacol. 2023 Jan 24. doi: 10.1111/bcp.15672.
4 Assessing Prolongation of the Corrected QT?Interval with Bedaquiline and Delamanid Coadministration to Predict the Cardiac Safety?of Simplified Dosing Regimens. Clin Pharmacol Ther. 2022 Oct;112(4):873-881. doi: 10.1002/cpt.2685.

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