| General Information of Drug Metabolite (DM) (ID: DM003430) |
| DM Name |
O-demethylated tetrandrine GSH conjugate
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A5 (CYP3A5)
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DME0012
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| Unclear - Unclear |
CBT-1
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| CBT-1 |
DR1570
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Phase 1 |
Histiocytic sarcoma |
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| References |
| 1 |
CYP3A5 mediates bioactivation and cytotoxicity of tetrandrine. Arch Toxicol. 2016 Jul;90(7):1737-48.
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