Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM005182)
DM Name	Beta-Ketophenylbutyryl-CoA
Structure
Structure	3D MOL is unavailable			2D MOL is unavailable

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
#NAME?	DMEN260	Beta-Hydroxyphenylbutyryl-CoA	Unclear - Unclear	Sodium phenylbutyrate	[1]
Beta-Hydroxyacyl-CoA Dehydrogenase (HSDB)	DMEN814	Beta-Hydroxyphenylbutyryl-CoA	Unclear - Unclear	Phenylbutyrate	[2]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Acetyl-CoA acetyltransferase (ACAT2)	DMEN261	Acetyl-CoA	Unclear - Unclear	Sodium phenylbutyrate	[1]
Acetyl-CoA acetyltransferase (ACAT2)	DMEN261	Acetyl-CoA	Unclear - Unclear	Phenylbutyrate	[2]
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM)	DMEN262	Phenylacetyl-CoA	Unclear - Unclear	Sodium phenylbutyrate	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Sodium phenylbutyrate		DR5509	Approved		Muscular atrophy

Phenylbutyrate		DR3191	Phase 2		Phenylketonuria

References
1	Evidence for involvement of medium chain acyl-CoA dehydrogenase in the metabolism of phenylbutyrate
2	Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control

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