| General Information of Drug Metabolite (DM) (ID: DM005791) |
| DM Name |
3alpha-17beta-disulfated-tibolone
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Sulfotransferase 1E1 (SULT1E1)
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DME0061
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| Conjugation - Sulfation |
Tibolone
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[1] , [2] , [3] |
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Sulfotransferase 2A1 (SULT2A1)
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DME0074
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| Conjugation - Sulfation |
Tibolone
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[1] , [2] , [3] |
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Sulfotransferase 2B1 (SULT2B1)
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DME0384
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| Conjugation - Sulfation |
Tibolone
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[1] , [2] , [3] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Tibolone |
DR1590
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Phase 4 |
Depression |
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| References |
| 1 |
Sulfation of tibolone and tibolone metabolites by expressed human cytosolic sulfotransferases. J Steroid Biochem Mol Biol. 2004 Apr;88(4-5):383-91.
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| 2 |
Sulfation of tibolone metabolites by human postmenopausal liver and small intestinal sulfotransferases (SULTs). Steroids. 2006 May;71(5):343-51.
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| 3 |
Antioxidant effect of the active metabolites of tibolone
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