| General Information of Drug Metabolite (DM) (ID: DM005944) |
| DM Name |
Dihydroxytriptolide
|
|
|
|
|
|
|
|
| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
|
Cytochrome P450 3A4 (CYP3A4)
|
DME0001
|
| Oxidation - Hydrolyzationn |
PG-490
|
[1] |
|
Mephenytoin 4-hydroxylase (CYP2C19)
|
DME0021
|
| Oxidation - Hydrolyzationn |
PG-490
|
[1] |
|
|
|
|
|
|
|
| DME(s) Metabolizing This DM |
| DME Name |
DME ID |
Product |
Reaction |
Related Drug |
REF |
|
Sulfotransferase (SULT)
|
DMEN061
|
| Conjugation - Conjugation |
PG-490
|
[1] |
|
Sulfotransferase (SULT)
|
DMEN061
|
| Conjugation - Conjugation |
PG-490
|
[1] |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Full List of Drug(s) That Produce This DM By Metabolism |
| PG-490 |
DR1904
|
Phase 3 |
Diabetes mellitus |
|
|
| References |
| 1 |
Preclinical pharmacokinetics of triptolide: a potential antitumor drug. Curr Drug Metab. 2019;20(2):147-154.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.
