| General Information of Drug Metabolite (DM) (ID: DM006004) |
| DM Name |
Tirapazamine radical
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 2E1 (CYP2E1)
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DME0013
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| Unclear - Unclear |
SR-4233
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| SR-4233 |
DR1602
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Phase 3 |
Alzheimer disease |
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| References |
| 1 |
Molecular mechanisms of tirapazamine (SR 4233, Win 59075)-induced hepatocyte toxicity under low oxygen concentrations. Br J Cancer. 1995 Apr;71(4):780-5.
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