Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM017050)
DM Name	Nor-levomethadyl acetate (nor-LAAM)

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 2B6 (CYP2B6)	DME0020	Levomethadyl Acetate	Oxidation - N-demethylation	Levomethadyl Acetate	[1] , [2]
Cytochrome P450 2C18 (CYP2C18)	DME0017	Levomethadyl Acetate	Oxidation - N-demethylation	Levomethadyl Acetate	[1] , [2]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Levomethadyl Acetate	Oxidation - N-demethylation	Levomethadyl Acetate	[1] , [2]
Cytochrome P450 3A7 (CYP3A7)	DME0015	Levomethadyl Acetate	Oxidation - N-demethylation	Levomethadyl Acetate	[1] , [2]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Cytochrome P450 3A7 (CYP3A7)	DME0015	Dinor-levomethadyl acetate	Unclear - Unclear	Levomethadyl Acetate	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Levomethadyl Acetate		DR5230	Approved		Opiate dependence

References
1	The KEGG resource for deciphering the genome
2	Differential N-demethylation of l-alpha-acetylmethadol (LAAM) and norLAAM by cytochrome P450s 2B6, 2C18, and 3A4

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