| General Information of Drug Metabolite (DM) (ID: DM017346) |
| DM Name |
PPI-2458 metabolite M1
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - Hydroxylation |
PPI-2458
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[1] |
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Cytochrome P450 3A5 (CYP3A5)
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DME0012
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| Oxidation - Hydroxylation |
PPI-2458
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| PPI-2458 |
DR3090
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Phase 1 |
Diabetes mellitus |
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| References |
| 1 |
Metabolites of PPI-2458, a selective, irreversible inhibitor of methionine aminopeptidase-2: structure determination and in vivo activity. Drug Metab Dispos. 2013 Apr;41(4):814-26.
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