| General Information of Drug Metabolite (DM) (ID: DM017933) |
| DM Name |
Siponimod M7
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 2C9 (CYP2C9)
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DME0019
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| Oxidation - Hydroxylation |
BAF-312
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[1] |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - Hydroxylation |
BAF-312
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| BAF-312 |
DR1488
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Phase 3 |
Multiple sclerosis |
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| References |
| 1 |
Metabolism and disposition of siponimod, a novel selective S1P1/S1P5 agonist, in healthy volunteers and in vitro identification of human cytochrome P450 enzymes involved in its oxidative metabolism. Drug Metab Dispos. 2018 Jul;46(7):1001-1013.
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