General Information of Drug Metabolite (DM) (ID: DM018294)
DM Name
IC200161
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - Dealkylation ITI-007 [1]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - Dealkylation lumateperone tosylate [2]
Full List of Drug(s) That Produce This DM By Metabolism
lumateperone tosylate DR5480 Approved Schizophrenia
ITI-007 DR3407 Phase 3 Schizophrenia
References
1 An evaluation of lumateperone tosylate for the treatment of schizophrenia
2 Dopamine D(2) receptor occupancy of lumateperone (ITI-007): a Positron Emission Tomography Study in patients with schizophrenia

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