Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0100)
Drug Name
Ammonia
Synonyms
Aminomethyl Polystyrene Resin; Ammonia (conc 20% or greater); Ammonia anhydrous; Ammonia gas; Ammonia, anhydrous; Ammoniac [French]; Ammoniaca [Italian]; Ammoniak; Ammoniak Kconzentrierter; Ammoniak [German]; Ammoniakgas; Amoniak [Polish]; Anhydrous ammonia; EPA Pesticide Chemical Code 005302; Liquid Ammonia; Nitro-sil; Spirit of hartshorn; UN 2073 (>44% solution); UN1005; ammonia; ammoniac; (Aminomethyl)polystyrene; AM-Fol; 7664-41-7; CCRIS 2278; Caswell No. 041; HSDB 162; NH3; R 717; UNII-5138Q19F1X; azane
Indication Atherosclerosis [ICD11: BA80] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 17.031 Topological Polar Surface Area 1
Heavy Atom Count 1 Rotatable Bond Count 0
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 1
Cross-matching ID
PubChem CID
222
ChEBI ID
CHEBI:16134
CAS Number
7664-41-7
TTD Drug ID
D0FT7Y
Formula
H3N
Canonical SMILES
N
InChI
1S/H3N/h1H3
InChIKey
QGZKDVFQNNGYKY-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Glutamate DM000317
33032
Unclear 1 [2]
L-arginine DM003102
6322
Unclear 1 [4]
L-citrulline DM000319
9750
Unclear 1 [4]
L-Glutamine DM001343
5961
Conjugation - Condensation 1 [2]
Urea DM001344
1176
Unclear 1 [5]
L-Glutamine DM001343
5961
Unclear 2 [6]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR000200 Ammonia L-glutamate Unclear GLUD11 [2]
MR000201 Ammonia L-citrulline Unclear Unclear [4]
MR000202 Ammonia Glutamine Conjugation - Condensation GLUL ... [2]
MR000203 Ammonia Urea Unclear Unclear [5]
MR000204 Ammonia L-arginine Unclear Unclear [4]
MR000199 L-glutamate Glutamine Unclear Unclear [6]
⏷ Show the Full List of 6 MR(s)
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Glutamate dehydrogenase 1 (GLUD1) DMEN032 Homo sapiens
DHE3_HUMAN
6.3.4.5
[2]
Glutamine synthetase (GLUL) DME0418 Homo sapiens
GLNA_HUMAN
6.3.1.2
[3]
L-glutamine amidohydrolase (GLS) DME0126 Homo sapiens
GLSK_HUMAN
3.5.1.2
[2]
References
1 Ammonia was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases J Hepatol. 2016 Apr;64(4):860-71. doi: 10.1016/j.jhep.2015.11.018.
3 Ammonia metabolism capacity of HepG2 cells with high expression of human glutamine synthetase. Hepatobiliary Pancreat Dis Int. 2008 Dec;7(6):621-7.
4 Ammonia metabolism and hyperammonemic disorders Adv Clin Chem. 2014;67:73-150. doi: 10.1016/bs.acc.2014.09.002.
5 Ammonia Transporters and Their Role in Acid-Base Balance Physiol Rev. 2017 Apr;97(2):465-494. doi: 10.1152/physrev.00011.2016.
6 Metabolism of glutamate and ammonia in astrocyte: an immunocytochemical study Brain Res. 1988 Aug 2;457(1):160-4. doi: 10.1016/0006-8993(88)90069-8.

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