Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN032)
DME Name Glutamate dehydrogenase 1 (GLUD1), Homo sapiens
Gene Name GLUD1
UniProt ID
DHE3_HUMAN
EC Number    EC: 6.3.4.5     (Click to Show/Hide the Complete EC Tree)
Ligase
Carbon-nitrogen ligase
Other carbon-nitrogen ligases
EC: 6.3.4.5
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MYRYLGEALLLSRAGPAALGSASADSAALLGWARGQPAAAPQPGLALAARRHYSEAVADR
EDDPNFFKMVEGFFDRGASIVEDKLVEDLRTRESEEQKRNRVRGILRIIKPCNHVLSLSF
PIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFG
GAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTY
ASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFG
DKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILG
FPKAKPYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLER
NIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGK
HGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYV
NAIEKVFKVYNEAGVTFT
Structure
1L1F ; 1NR1 ; 6DQG ;
Function Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. Plays a role in insulin homeostasis. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Ammonia
 Drug Info Approved Atherosclerosis ICD11: BA80 [1]
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Glutamic acid
 Drug Info Phase 3 Follicular lymphoma ICD11: 2A80 [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR000200 Ammonia L-glutamate Unclear - Unclear Ammonia [1]
MR003637 Glutamic acid Alpha-keto-glutarate Unclear - Unclear Glutamic acid [2]
References
1 Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases J Hepatol. 2016 Apr;64(4):860-71. doi: 10.1016/j.jhep.2015.11.018.
2 Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration

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