Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0518)
Drug Name
Disopyramide phosphate
Synonyms
Disopyramide; Disopiramida; Disopiramida [INN-Spanish]; Disopyramide Free Base; Disopyramidum; Disopyramidum [INN-Latin]; EINECS 223-110-2; H 3292; Isorythm; Lispine; MFCD00057366; Ritmodan; Rythmodan; SC 7031; SC-7031; Searle 703; UVTNFZQICZKOEM-UHFFFAOYSA-N; alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide; alpha-Diisopropylaminoethyl-alpha-phenylpyridine-2-acetamide; disopyramide; gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide; 3737/9/5; CHEBI:4657; CHEMBL517; Dicorantil; 2-(1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)pyridinium phosphate; 2-Pyridineacetamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-, phosphate (1:1); 2-Pyridineacetamide, alpha-(2-(diisopropylamino)ethyl)-alpha-phenyl-, phosphate; 22059-60-5; CHEBI:4658; DISOPYRAMIDE PHOSPHATE; DISOPYRAMIDE PHOSPHATE SALT; EINECS 244-756-1; Norpace; Norpace Cr; SC 13957; SC 7031 phosphate; SC-13957; Alpha-(2-Diisopropylaminoethyl)-alpha-phenyl-2-pyridineacetamide phosphate
Indication Ventricular tachyarrhythmia [ICD11: BC71] Approved [1]
Structure
3D MOL is unavailable 2D MOL
Pharmaceutical Properties Molecular Weight 437.5 Topological Polar Surface Area 137
Heavy Atom Count 30 Rotatable Bond Count 8
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 7
Cross-matching ID
PubChem CID
30928
ChEBI ID
CHEBI:4658
CAS Number
22059-60-5
TTD Drug ID
D0M4YC
Formula
C21H32N3O5P
Canonical SMILES
CC(C)N(CCC(C1=CC=CC=C1)(C2=CC=CC=N2)C(=O)N)C(C)C.OP(=O)(O)O
InChI
1S/C21H29N3O.H3O4P/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19;1-5(2,3)4/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25);(H3,1,2,3,4)
InChIKey
CGDDQFMPGMYYQP-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Mono-isopropyl-disopyramide DM000112
107858
Oxidation - N-Dealkylation 1 [2] , [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR000880 Disopyramide phosphate Mono-isopropyl-disopyramide Oxidation - N-Dealkylation CYP3A4 [2], [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 1A2 (CYP1A2) DME0003 Homo sapiens
CP1A2_HUMAN
1.14.14.1
[2]
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[2]
References
1 Disopyramide Phosphate was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Species difference in stereoselective involvement of CYP3A in the mono-N-dealkylation of disopyramide. Xenobiotica. 2001 Feb;31(2):73-83.
3 LABEL:ISOPYRAMIDE PHOSPHATE capsule, gelatin coated

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