Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0680)
Drug Name
Famotidine
Synonyms
Fagastine; Famodil; Famotidina [Spanish]; Famotidinum [Latin]; Famoxal; Famtac; Famulcer; Fanobel; Fanosin; Farmotex; Ferotine; Fibonel; Fluxid; Fudone; Gaster; Gastridin; Nu-Famotidine; PEPCID; Pepcid AC; Pepcid RPD; Pepcidin Rapitab; Antodine; Apogastine; Bestidine; Dibrit 40; Digervin; Dipsin; Dispromil; Dispronil; Duovel; Durater; Evatin; Fadine; Pepcidina; Pepcidine; Pepdif; Pepdine; Pepdul; Peptifam; Pepzan; Quamatel; Sedanium-R; Sigafam; Supertidine; Tairal; Weimok; Whitidin; Yamarin; famotidine; 76824-35-6; Dinul; Fadin; Fadyn; Famo; Famox; Fanox; Ganor
Indication Peptic ulcer [ICD11: DA61] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 337.5 Topological Polar Surface Area 238
Heavy Atom Count 20 Rotatable Bond Count 7
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 8
Cross-matching ID
PubChem CID
5702160
PubChem SID
219459 ; 855518 ; 7847384 ; 7979217 ; 10321312 ; 11111194 ; 11111195 ; 11736775 ; 12013748 ; 14777800 ; 14900130 ; 14900131 ; 17405060 ; 24278442 ; 26719681 ; 26753575 ; 46386903 ; 47350438 ; 47425376 ; 47721689 ; 47957418 ; 48108291 ; 48244468 ; 48407560 ; 48415998 ; 49681730 ; 49698346 ; 49835099 ; 49846705 ; 50022089 ; 50100994 ; 50100995 ; 50106279 ; 50106280 ; 53777603 ; 57364911 ; 76715592 ; 77320398 ; 81093272 ; 85211955 ; 85220228 ; 85231052 ; 87558227 ; 90340682 ; 90501992 ; 91704175 ; 92125054 ; 92303791 ; 92308237 ; 92308848
ChEBI ID
ChEBI:4975
CAS Number
76824-35-6
TTD Drug ID
D0K0OZ
Formula
C8H15N7O2S3
Canonical SMILES
C1=CC(=C(C(=C1)Cl)C=NN=C(N)N)Cl
InChI
1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
InChIKey
XUFQPHANEAPEMJ-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Famotidine S-oxide DM000143
13949559
Oxidation - Oxidation 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR001010 Famotidine Famotidine S-oxide Oxidation - Oxidation Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Homo sapiens
CP2CJ_HUMAN
1.14.14.1
[2]
References
1 Famotidine was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Initial 48-hour acid inhibition by intravenous infusion of omeprazole, famotidine, or both in relation to cytochrome P450 2C19 genotype status. Clin Pharmacol Ther. 2006 Nov;80(5):539-48.
3 McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 1999. Bethesda, MD:American Society of Health-System Pharmacists, Inc. 1999 (Plus Supplements)., p. 1760

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