Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0735)
Drug Name
Fluticasone furoate
Synonyms
Flonase Sensimist; Fluticasone fuorate; Fluticasone furoate; Fluticasone furoate [USAN:INN]; Furamist; JS86977WNV; Veramyst; Veramyst (TN); fluticasonum furoas; furoate de fluticasone; furoato de fluticasona; (6alpha,11alpha,14beta,16alpha,17alpha)-6,9-Difluoro-17-{[(Fluoromethyl)sulfanyl]carbonyl}-11-Hydroxy-16-Methyl-3-Oxoandrosta-1,4-Dien-17-Yl Furan-2-Carboxylate; 397864-44-7; CHEBI:74899; GSK 685 698; GSK 685698; GW 685698; GW 685698X; GW685698X; UNII-JS86977WNV; Alisade; Allermist; Arnuity Ellipta; Avamys
Indication Allergic rhinitis [ICD11: CA08] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 538.6 Topological Polar Surface Area 119
Heavy Atom Count 37 Rotatable Bond Count 6
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 10
Cross-matching ID
PubChem CID
9854489
ChEBI ID
CHEBI:74899
CAS Number
397864-44-7
TTD Drug ID
D0LC6K
Formula
C27H29F3O6S
Canonical SMILES
CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)SCF)OC(=O)C5=CC=CO5)C)O)F)C)F
InChI
1S/C27H29F3O6S/c1-14-9-16-17-11-19(29)18-10-15(31)6-7-24(18,2)26(17,30)21(32)12-25(16,3)27(14,23(34)37-13-28)36-22(33)20-5-4-8-35-20/h4-8,10,14,16-17,19,21,32H,9,11-13H2,1-3H3/t14-,16+,17+,19+,21+,24+,25+,26+,27+/m1/s1
InChIKey
XTULMSXFIHGYFS-VLSRWLAYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Acid Metabolite of Fluticasone Furoate DM004704
10163423
Hydrolysis - Hydrolyzation 1 [4]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR005056 Fluticasone furoate Acid Metabolite of Fluticasone Furoate Hydrolysis - Hydrolyzation Unclear [4]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[2]
Cytochrome P450 3A5 (CYP3A5) DME0012 Homo sapiens
CP3A5_HUMAN
1.14.14.1
[2]
Cytochrome P450 3A7 (CYP3A7) DME0015 Homo sapiens
CP3A7_HUMAN
1.14.14.1
[3]
References
1 Fluticasone Furoate was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev. 2010 Nov;42(4):621-35.
3 Biotransformation of fluticasone: in vitro characterization. Drug Metab Dispos. 2006 Jun;34(6):1035-40.
4 Fluticasone furoate/fluticasone propionate - different drugs with different properties

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