Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0755)
Drug Name
Frovatriptan
Synonyms
Frovatriptan; Frovatriptan (INN); Frovatriptan [INN:BAN]; Frovelan; Miguard; Rilamig; Allegro; Auradol; SB 209509; (3R)-3-(methylamino)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide; (6R)-6-(methylamino)-6,7,8,9-tetrahydro-5H-carbazole-3-carboxamide; (R)-5,6,7,8-Tetrahydro-6-(methylamino)carbazole-3-carboxamide; 158747-02-5; 1H-Carbazole-6-carboxamide, 2,3,4,9-tetrahydro-3-(methylamino)-, (3R)-; 1H-Carbazole-6-carboxamide, 2,3,4,9-tetrahydro-3-(methylamino)-, (R)-; CHEMBL1279; Frova; H82Q2D5WA7; HSDB 7363; UNII-H82Q2D5WA7
Indication Migraine [ICD11: 8A80] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 243.3 Topological Polar Surface Area 70.9
Heavy Atom Count 18 Rotatable Bond Count 2
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 2
Cross-matching ID
PubChem CID
77992
PubChem SID
7979332 ; 8199305 ; 12014901 ; 14749650 ; 15221001 ; 43133577 ; 46506288 ; 48416039 ; 50070536 ; 50071300 ; 50288893 ; 57332463 ; 93167160 ; 96024690 ; 103396317 ; 103967002 ; 104368726 ; 126658118 ; 126667006 ; 129723338 ; 134223840 ; 134337391 ; 135035469 ; 137002444 ; 138365609 ; 160964334 ; 175265638 ; 178103766 ; 179150020 ; 184527647 ; 223660569 ; 226420875
ChEBI ID
CHEBI:134991
CAS Number
158747-02-5
TTD Drug ID
D06FPQ
Formula
C14H17N3O
Canonical SMILES
CNC1CCC2=C(C1)C3=C(N2)C=CC(=C3)C(=O)N
InChI
1S/C14H17N3O/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18)/t9-/m1/s1
InChIKey
XPSQPHWEGNHMSK-SECBINFHSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Desmethyl frovatriptan DM002079
40466922
Unclear 1 [2]
Hydroxylated frovatriptan DM002080 N. A. Unclear 1 [3]
Hydroxylated N-acetyl desmethyl frovatriptan DM002081
131770052
Unclear 1 [3]
N-acetyl desmethyl frovatriptan DM002082
131770056
Unclear 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR001093 Frovatriptan Desmethyl frovatriptan Unclear CYP1A2 [2]
MR001094 Frovatriptan Hydroxylated frovatriptan Unclear CYP1A2 [3]
MR001095 Frovatriptan Hydroxylated N-acetyl desmethyl frovatriptan Unclear CYP1A2 [3]
MR001096 Frovatriptan N-acetyl desmethyl frovatriptan Unclear CYP1A2 [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 1A2 (CYP1A2) DME0003 Homo sapiens
CP1A2_HUMAN
1.14.14.1
[2]
References
1 Frovatriptan was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Frovatriptan: a review of drug-drug interactions. Headache. 2002 Apr;42 Suppl 2:S63-73.
3 DrugBank(Pharmacology-Metabolism)Frovatriptan

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