Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0779)
Drug Name
Gliquidone
Synonyms
Gliquidona; Gliquidona [INN-Spanish]; Gliquidone; Gliquidonum; Gliquidonum [INN-Latin]; Glurenorm; glikvidon; glycvidon; Beglynor; Beglynora; 1-cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxoisoquinolin-2-yl)ethyl]phenyl]sulfonylurea; 33342-05-1; BRN 1559726; C27H33N3O6S; C7C2QDD75P; CAS-33342-05-1; DSSTox_CID_3096; DSSTox_GSID_23096; DSSTox_RID_76873; EINECS 251-463-2; MFCD00631870; NCGC00016819-01; ARDF 26; ARDF 26 SE; UNII-C7C2QDD75P
Indication Diabetes mellitus [ICD11: 5A10] Phase 4 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 527.6 Topological Polar Surface Area 130
Heavy Atom Count 37 Rotatable Bond Count 7
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
91610
PubChem SID
7449309 ; 7849488 ; 7979418 ; 10224909 ; 11112731 ; 11467019 ; 11468139 ; 11486708 ; 14860897 ; 44422540 ; 46508425 ; 47381693 ; 47381694 ; 47604985 ; 47901629 ; 48351264 ; 48416055 ; 49699236 ; 49832468 ; 49881412 ; 50060569 ; 50085433 ; 50124024 ; 50796154 ; 56463591 ; 57334969 ; 81041002 ; 81065941 ; 81092899 ; 85787540 ; 87560715 ; 92125987 ; 92717029 ; 103481945 ; 103914607 ; 104405238 ; 105585086 ; 121363658 ; 124882576 ; 124882577 ; 125204729 ; 125348208 ; 126622557 ; 126654118 ; 126739661 ; 128505786 ; 131310850 ; 134338200 ; 135049036 ; 137005778
ChEBI ID
CHEBI:93416
CAS Number
33342-05-1
TTD Drug ID
D06HBQ
Formula
C27H33N3O6S
Canonical SMILES
CC1(C2=C(C=C(C=C2)OC)C(=O)N(C1=O)CCC3=CC=C(C=C3)S(=O)(=O)NC(=O)NC4CCCCC4)C
InChI
1S/C27H33N3O6S/c1-27(2)23-14-11-20(36-3)17-22(23)24(31)30(25(27)32)16-15-18-9-12-21(13-10-18)37(34,35)29-26(33)28-19-7-5-4-6-8-19/h9-14,17,19H,4-8,15-16H2,1-3H3,(H2,28,29,33)
InChIKey
LLJFMFZYVVLQKT-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Unclear DM009999 N. A. Unclear 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR007229 Gliquidone Unclear Unclear CYP3A4 ... [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 2C9 (CYP2C9) DME0019 Homo sapiens
CP2C9_HUMAN
1.14.14.1
[2]
References
1 ClinicalTrials.gov (NCT00568074) Efficacy and Safety of Repaglinide, Glurenorm® and Glucobay® in Chinese Subjects With Type 2 Diabetes.
2 Clinically and pharmacologically relevant interactions of antidiabetic drugs. Ther Adv Endocrinol Metab. 2016 Apr;7(2):69-83.
3 Contribution of cytochrome P450 isoforms to gliquidone metabolism in rats and human

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