Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0850)
Drug Name
Icodextrin
Synonyms
Icode-xtrin; CTK4H1147; DSSTox_CID_25666; DSSTox_GSID_45666; ICODEXTRIN; DivK1c_000010; Prestwick0_000096; Prestwick1_000096; SPBio_001248; SPBio_001991; Spectrum2_001114; Spectrum3_000445; Spectrum4_000567; Spectrum_000843; WDZVGELJXXEGPV-UHFFFAOYSA-N; 60329-03-5; AC1L1G45; CAS-5051-62-7; CHEMBL1313657; DSSTox_RID_81042; DTXSID6045666; Hydrazinecarboximidamide, 2-[(2,6-dichlorophenyl)methylene]-, (E)-; KBio1_000010; KBio2_001323; KBio2_003891; KBio2_006459; KBio3_001310; KBioGR_000974; KBioSS_001323; NCGC00024846-03
Indication Peritonitis [ICD11: DC50] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 231.08 Topological Polar Surface Area 76.8
Heavy Atom Count 14 Rotatable Bond Count 2
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 2
Cross-matching ID
PubChem CID
3517
CAS Number
337376-15-5
TTD Drug ID
D02YCH
Formula
C8H8Cl2N4
Canonical SMILES
C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl.Cl
InChI
1S/C8H8Cl2N4/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12/h1-4H,(H4,11,12,14)/b13-4+
InChIKey
WDZVGELJXXEGPV-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Maltose DM004269
10991489
Unclear 1 [3] , [4]
Maltotetraose DM004271
439639
Unclear 1 [3]
Maltotriose DM004270
439586
Unclear 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR004646 Icodextrin Maltose Unclear Unclear [3], [4]
MR004647 Icodextrin Maltotriose Unclear Unclear [3]
MR004648 Icodextrin Maltotetraose Unclear Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Pancreatic alpha-amylase (AMY2A) DME0148 Homo sapiens
AMYP_HUMAN
3.2.1.1
[2]
References
1 Icodextrin was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Analytical interferences in point-of-care testing glucometers by icodextrin and its metabolites: an overview. Perit Dial Int. 2009 Jul-Aug;29(4):377-83.
3 Clinical experience with icodextrin in children: ultrafiltration profiles and metabolism
4 Avoidable iatrogenic hypoglycemia in patients on peritoneal dialysis: the risks of nonspecific glucose monitoring devices and drug-device interaction

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