Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0981)
Drug Name
Lornoxicam
Synonyms
Lorcam; Lorcam (TN); Lornoxicam; Lornoxicam (Xefo); Lornoxicam [USAN:INN:BAN]; Lornoxicamum; Lornoxicamum [INN-Latin]; Ro 13-9297; Taigalor; Chlortenoxicam; ER09126G7A; Xefocam; 2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide; 6-Chloro-4-hydroxy-2-methyl-N-2-pyridyl-2H-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide; 70374-39-9; Acabel; BRN 1039965; C13H10ClN3O4S2; CCRIS 8589; CHEBI:31783; CLTX; MFCD00866163; Safem; Telos; UNII-ER09126G7A; Xefo
Indication Myocardial infarction [ICD11: BA41] Phase 4 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 371.8 Topological Polar Surface Area 136
Heavy Atom Count 23 Rotatable Bond Count 2
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 7
Cross-matching ID
PubChem CID
54690031
ChEBI ID
CHEBI:31783
CAS Number
70374-39-9
TTD Drug ID
D0UL2L
Formula
C13H10ClN3O4S2
Canonical SMILES
CN1C(=C(C2=C(S1(=O)=O)C=C(S2)Cl)O)C(=O)NC3=CC=CC=N3
InChI
1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19)
InChIKey
WLHQHAUOOXYABV-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
5-hydroxylornoxicam DM002602
54691489
Oxidation - HYDROXYLATION 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR009967 Lornoxicam 5-hydroxylornoxicam Oxidation - HYDROXYLATION CYP2C9 [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 2C9 (CYP2C9) DME0019 Homo sapiens
CP2C9_HUMAN
1.14.14.1
[2]
References
1 ClinicalTrials.gov (NCT00997750) Efficacy and Safety of Lornoxicam in Patients With Acute Coronary Syndrome.
2 Prediction of pharmacokinetic drug/drug interactions from In vitro data: interactions of the nonsteroidal anti-inflammatory drug lornoxicam with oral anticoagulants. Drug Metab Dispos. 2000 Feb;28(2):161-8.
3 Effect of the CYP2C9*3 allele on lornoxicam metabolism

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